Cefovecin
Synonym(s): Convenia
Introduction
Name
- Cefovecin.
Class of drug
- Third generation cephalosporin antimicrobial.
Description
Chemical name
- (6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[(2S)-tetrahydro-2-furanyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monosodium salt.
Molecular formula
- C17H18N5NaO6S2
Molecular weight
- 475.47
Physical properties
- The powder is off-white to yellow and the diluent is a clear, colorless liquid.
- Each vial of lyophilized powder contains 852 mg Cefovecin (as sodium salt), containing methylparahydroxybenzoate (E218) and propyl parahydroxybenzoate (E216) as excipients.
- In Europe lyophilized powder has to be reconstituted with a specific diluent containing 13 mg/ml benzyl alcohol and 10.8 ml water for injections, yielding an 80.0 mg/ml solution of Cefovecin.
- In common with other cephalosporin antibiotics, the color of the solution darkens over time. Potency is not affected when the solution is stored as described.
Storage requirements
- Store powder and the reconstituted product in original carton, refrigerated at 2-8°C (32-46°F). Use entire contents of the vial within 28 days of reconstitution.
- Protect from light.
Uses
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Administration
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Pharmacokinetics
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Precautions
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Withdrawal Periods
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Adverse Reactions
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
- Six R et al (2009) Effectiveness of cefovecin sodium for the treatment of cats with abscesses and infected wounds. JAVMA 234, 81-87 PubMed.
- Passmore C A, Sherington J, Stegemann M R (2008) Efficacy and safety of Cefovecin (Convenia®) for the treatment of urinary tract infections in cats. JSAP 49 (6), 295 PubMed.
- Stegemann M R, Sherington J, Passmore C A (2007) The efficacy and safety of Cefovecin (Convenia®) in the treatment of feline abscesses and infected wounds. JSAP 48 (12), 683-689 PubMed.
- Stegemann M R, Passmore C A, Sherington J, Lindeman C J, Papp G, Weigel D J, Skogerboe T L (2006) Antimicrobial activity and spectrum of cefovecin, a new extended- spectrum cephalosporin, against pathogens collected from dogs and cats in Europe and North America. Antimicrob Agents Chemother 50 (7), 2286-2292 PubMed.
Other sources of information
- www.convenia.com/pdfs/Convenia_prescribing_information.pdf.
- www.emea.europa.eu EPARs for authorized veterinary medicinal products.
- European Medicines Agency (online) Categorisation of Antibiotics for Use in Animals for Prudent and Responsible Use. Website: www.ema.europa.eu (pdf download).