Cefovecin in Cats (Felis) | Vetlexicon
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Cefovecin

ISSN 2398-2950

Contributor(s) :


Synonym(s): Convenia

Introduction

In the UK, Cefovecin is classified as category B (Restrict) by the European Medicines Agency (EMA).

Name

  • Cefovecin.

Class of drug

  • Third generation cephalosporin antimicrobial.

Description

Chemical name

  • (6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[(2S)-tetrahydro-2-furanyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monosodium salt.

Molecular formula

  • C17H18N5NaO6S2

Molecular weight

  • 475.47

Physical properties

  • The powder is off-white to yellow and the diluent is a clear, colorless liquid.
  • Each vial of lyophilized powder contains 852 mg Cefovecin (as sodium salt), containing methylparahydroxybenzoate (E218) and propyl parahydroxybenzoate (E216) as excipients.
  • In Europe lyophilized powder has to be reconstituted with a specific diluent containing 13 mg/ml benzyl alcohol and 10.8 ml water for injections, yielding an 80.0 mg/ml solution of Cefovecin.
  • In common with other cephalosporin antibiotics, the color of the solution darkens over time. Potency is not affected when the solution is stored as described.

Storage requirements

  • Store powder and the reconstituted product in original carton, refrigerated at 2-8°C (32-46°F). Use entire contents of the vial within 28 days of reconstitution.
  • Protect from light.
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Uses

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Administration

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Pharmacokinetics

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Precautions

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Withdrawal Periods

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Six R et al (2009) Effectiveness of cefovecin sodium for the treatment of cats with abscesses and infected wounds. JAVMA 234, 81-87 PubMed.
  • Passmore C A, Sherington J, Stegemann M R (2008) Efficacy and safety of Cefovecin (Convenia®) for the treatment of urinary tract infections in cats. JSAP 49 (6), 295 PubMed.
  • Stegemann M R, Sherington J, Passmore C A (2007) The efficacy and safety of Cefovecin (Convenia®) in the treatment of feline abscesses and infected wounds. JSAP 48 (12), 683-689 PubMed.
  • Stegemann M R, Passmore C A, Sherington J, Lindeman C J, Papp G, Weigel D J, Skogerboe T L (2006) Antimicrobial activity and spectrum of cefovecin, a new extended- spectrum cephalosporin, against pathogens collected from dogs and cats in Europe and North America. Antimicrob Agents Chemother 50 (7), 2286-2292 PubMed.

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