Ciclosporin
Synonym(s): Cyclosporine, Ciclosporin A, Cyclosporine A
Introduction
Name
- Ciclosporin.
Class of drug
- Immunosuppressive agent.
Description
Chemical name
- Ciclosporin A.
Molecular formula
- C62H111N11O12.
Physical properties
- Available in the following formulations (not all licensed for use in cats):
- Eye ointment.
- Eye drops.
- Capsules.
- Solution for injection.
- Solution for oral administration.
Storage requirements
- <25°C/77°F.
- Oral solution: a jelly-like formation may occur below 15°C/59°F which is however reversible at temperatures up to 25°C/77°F without affecting the quality of the product.
Uses
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Administration
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Pharmacokinetics
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Precautions
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Adverse Reactions
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
- Noli C & Scarampella F (2006) Prospective open pilot study on the use of ciclosporin for feline allergic skin disease. JSAP 47, 434-438.
- Last R D, Suzuki, Y, Manning T Iet al (2004) A case of fatal systemic toxoplasmosis in a cat being treated with cyclosporin A for feline atopy. Vet Dermatol 15 (3), 194-198. WileyOnline
- Mehl M L, Kyles A E, Craigmill A L et al (2003) Disposition of cyclosporine after intravenous and multi-dose oral administration in cats. .J Vet Pharmacol Ther 26 (5), 349. WileyOnline
Other sources of information
- Novartis Pharmaceuticals UK Ltd (2024) Sandimmun Concentrate for Solution for Infusion 50 mg/mL (human authorized medicine). Website: www.medicines.org.uk.
- Virbac UK (2024) Cyclavance 100 mg/mL Oral Solution for Cats and Dogs. Website: www.vmd.defra.gov.uk; uk.virbac.com
- Elanco (2023) Atopica 100 mg/mL Oral Solution for Cats and Dogs. Website: www.vmd.defra.gov.uk
- Elanco (2023) Atopica Soft Capsules for Dogs, 10 mg, 25 mg, 50 mg, 100 mg. Website: www.vmd.defra.gov.uk
- Allerton F (2023) Small Animal Formulary.11th edn. BSAVA, UK.
- MSD Animal Health UK Limited (2021) Optimune 2 mg/g Eye Ointment for Dogs. Website: www.vmd.defra.gov.uk
- Le Vet Beheer B.V (2018) Sporimune 100 mg/mL Oral Solution for Cats and Dogs. Website: www.vmd.defra.gov.uk
- Regnier A & Ward D (1999) Clinical Pharmacology and Therapeutics. In: Veterinary Ophthalmology. 3rd edn. Ed Gelatt K Lippincott, Williams and Wilkins, USA.
- Plumbs (online) VetMedux, USA. Website: www.plumbs.com.