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Eprinomectin
Introduction
Name
- Eprinomectin.
Class of drug
- Avermectin.
- Macrocyclic lactone.
Description
Chemical name
- (1'R,2S,4'S,5S,6R,8
'R,10'E,12'S,13'S,1 4'E,16'E,20'R,21'R, 24'S)-21',24'-Dihyd roxy-6-isopropyl-5, 11',13',22'-tetrame thyl-2'-oxo-5,6-dih ydrospiro[pyran-2,6 '-[3,7,19]trioxatet racyclo[15.6.1.14,8 .020,24 ]pentacosa[10,14,16 ,22]tetraen]-12'-yl 4-O-(4-acetamido-2 ,4,6-trideoxy-3-O-m ethyl-α-L-lyxo-hexo pyranosyl)-2,6-dide oxy-3-O-methyl-α-L- arabino-hexopyranos ide - (1'R,2S,4'S,5 S,6R,8'R,10'E,12'S, 1 3'S,14'E ,16'E,20'R,21'R,24' S)-6-[(2S)-2-buta.
Molecular formula
- C99H148N2O28.
Molecular weight
- 1814.231.
Physical properties
- Spot-on solution in combination with praziquantel (Centragard, US).
- Spot-on solution in combination with fipronil, (S)-methoprene, praziquantel (Broadline, EU).
Uses
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Administration
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Pharmacokinetics
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Precautions
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Withdrawal Periods
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Adverse Reactions
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Further Reading
Publications
Refereed Papers
- Recent references from VetMedResource and PubMed.
- Giannelli A, Brianti E, Varcasia A et al (2015) Efficacy of Broadline® spot-on against Aelurostrongylus abstrusus and Troglostrongylus brevior lungworm in naturally infected cats from Italy. Vet Parasitol 209 (3-4), 273-277 PubMed.
- Knaus M, Shukullari E, Rapti D et al (2015) Efficacy of Broadline against Capillaria aerophila lungworm infection in cats. Parasitol Res 114 (5), 1971-1975 PubMed.
- Baker C F, Tielemans E, Pollmeier M G et al (2014) Efficacy of a single dose of a novel topical combination product containing eprinomectin to prevent heartworm infection in cats. Vet Parasitol 202 (1-2), 49-53 PubMed.
- Knaus M, Abu-Madi M A, Ibarra-Velarde F et al (2014) Efficacy of a novel topical fipronil, (S)-methoprene, eprinomectin and praziquantel combination against naturally acquired intestinal nematode and cestode infection in cats. Vet Parasitol 202 (1-2), 18-25 PubMed.
- Knaus M, Baker C F, Reinemeyer C R et al (2014) Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against adult and larval stages of Toxocara cati in cats. Vet Parasitol 202 (1-2), 34-39 PubMed.
- Knaus M, Chester S T, Rosentel J et al (2014) Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against larval and adult stages of the cat lungworm, Aelurostrongylus abstrusus. Vet Parasitol 202 (1-2), 64-68 PubMed.
- Knaus M, Shukallari E, Rosental J et al (2014) Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against feline urinary bladder worm (Capillaria plica) infection. Vet Parasitol 202 (1-2), 45-48 PubMed.
- Knaus M, Theodore Chester S, Rosentel J et al (2014) Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against experimental infections of Toxascaris leonina in cats. Vet Parasitol 202 (1-2), 40-44 PubMed.
- Kvaternick V, Kellermann M, Knaus M et al (2014) Pharmacokinetics and metabolism of eprinomectin in cats when administered in a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel. Vet Parasitol 202 (1-2), 2-9 PubMed.
- Prullage J B, Knaus M, Bowman D D et al (2014) Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against induced infections of Ancylostoma spp. nematodes of cats. Vet Parasitol 202 (1-2), 30-33 PubMed.
- Rehbein S, Cap��ri B, Duscher G et al (2014) Efficacy against nematode and cestode infections and safety of a novel topical fipronil, (S)-methoprene, eprinomectin and praziquantel combination product in domestic cats under field conditions in Europe. Vet Parasitol 202 (1-2), 10-17 PubMed.
Other sources of information
- Ramsey I (2017) BSAVA Small Animal Formulary. 9th edn. British Small Animal Veterinary Association, UK. pp 143.
- Chemspider (2015) Eprinomectin. [online] Available at: www.chemspider.com.
- Bishop Y (2005) Ed The Veterinary Formulary. 6th edn. Pharmaceutical Press. ISBN: 0-85369-579-2.
- European Medicines Agency. Broadline Summary of Product Characteristics : https://www.ema.europa.eu/documents/product-information/broadline-epar-product-information_en.pdf
- Food and Drugs Administration. Centragard™ eprinomectin and praziquantel transdermal solution for cats. Freedom of Information Summary : https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/3308