felis - Articles
Emodepside
Synonym(s): Profender (+ praziquantel), Felpreva (+praziquantel and tigolaner)
Introduction
Name
- Emodepside.
Class of drug
- Anthelmintic.
- Octadepsipeptide (depsipeptide).
Description
Chemical name
- N-methylated 24-membered cyclooctadepsipeptide, consisting of 4 alternating residues of N-methyl-L-leucine, 2 residues of D-lactate, and 2 residues of D-phenylacetate.
Molecular formula
- C60H90N6O14
Molecular weight
- 1119.4
Physical properties
- Used topically as a spot-on solution and orally as a suspension and as modified-release tablets. Suspension - shake well before use.
Uses
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Administration
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Pharmacokinetics
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Precautions
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Withdrawal Periods
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Adverse Reactions
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Further Reading
Publications
Refereed Papers
- Recent references from PubMed and VetMedResource.
- Crisi P E, Di Cesare A, Traversa D, Vignoli M, Morelli S, Di Tommaso M, De Santis F, Pampurini F, Schaper R, Boari A (2020) Controlled field study evaluating the clinical efficacy of a topical formulation containing emodepside and praziquantel in the treatment of natural cat aelurostrongylosis. Vet Rec 187(5), e34 PubMed.
- Traversa D, Veronesi F, Danesi P, Morelli S, Crisi P E, Morganti G, Iorio R, Pampurini F, Schaper R, Santoro A, Paoletti B, Di Cesare A (2019) Pilot study evaluating the efficacy of a topical formulation containing emodepside and praziquantel in the treatment of natural feline troglostrongylosis. Parasit Vectors 12(1), 97 PubMed.
- B��hm C, Petry G, Schaper R, Wolken S, Strube C (2015) Prevention of lactogenic Toxocara cati infections in kittens by application of an emodepside/praziquantel spot-on (Profender®) to the pregnant queen. Parasitol Res 114 Suppl 1, S175-184 PubMed.
- B��hm C, Wolken S, Schnyder M, Basso W, Deplazes P, Di Cesare A, Deuster K, Schaper R (2015) Efficacy of emodepside/praziquantel spot-on (Profender) against adult Aelurostrongylus abstrusus nematodes in experimentally infected cats. Parasitol Res 114 Suppl 1, S155-164 PubMed.
- Di Cesare A, Iorio R, Crisi P, Paoletti B, Di Costanzo R, Dimitri C F, Traversa D J (2015) Treatment of Troglostrongylus brevior (Metastrongyloidea, Crenosomatidae) in mixed lungworm infections using spot-on emodepside. J Feline Med Surg 17(2), 181-185 PubMed.
- Taweethavonsawat P, Chungpivat S, Watanapongchati S, Traub R J, Schaper R (2013) Comparative efficacy of a spot-on formulation containing emodepside and praziquantel (Profender , Bayer) and praziquantel and pyrantel oral tablets (Drontal for Cats) against experimental Ancylostoma ceylanicum infections in cats. Vet Parasitol 191(1-2), 172-176 PubMed.
- Wolken S, B��hm C, Schaper R, Schnieder T (2012) Treatment of third-stage larvae of Toxocara cati with milbemycin oxime plus praziquantel tablets and emodepside plus praziquantel spot-on formulation in experimentally infected cats. Parasitol Res 111(5), 2123-2127 PubMed.
Organisation(s)
- European Medicines Agency (2021) Felpreva Positive Opinion: https://www.ema.europa.eu/en/medicines/veterinary/summaries-opinion/felpreva
- European Medicines Agency (2005) Profender Summary of Product Characteristics: https://www.ema.europa.eu/en/documents/product-information/profender-epar-product-information_en.pdf
- National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
- VMD Product Information Database: https://www.vmd.defra.gov.uk/ProductInformationDatabase