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Toceranib phosphate
Synonym(s): Palladia
Introduction
Name
- Toceranib phosphate.
Class of drug
- A tyrosine kinase (TK) inhibitor.
Description
Chemical name
- (Z)-5-[(5-Fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide phosphate.
Molecular formula
- C22H25FN4O2H3O4P
Molecular weight
- 494.46
Storage requirements
- Store at controlled room temperature 20°-25°C (68°-77°F).
Uses
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Administration
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Pharmacokinetics
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Precautions
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Withdrawal Periods
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Adverse Reactions
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Further Reading
Publications
Refereed Papers
- Recent references from PubMed and VetMedResource.
- Keepman S J, Pellin M A (2022) Low dose meloxicam is safe and tolerable when combined with toceranib phosphate in cancer-bearing cats. J Feline Med Surg 24(12), 1187-1194 PubMed DOI: 10.1177/1098612X211067023.
- Berger E P, Johannes C M, Post G S, Rothchild G, Shiu K B, Wetzel S, Fox L E (2018) Retrospective evaluation of toceranib phosphate (Palladia) use in cats with mast cell neoplasia. J Feline Med Surg 20(2), 95-102 PubMed DOI: 10.1177/1098612X17695898.
- Harper A, Blackwood L (2017) Toxicity and response in cats with neoplasia treated with toceranib phosphate. J Feline Med Surg 19(6), 619-623 PubMed DOI: 10.1177/1098612X1664312.
- Merrick C H, Pierro J, Schleis S E, Sones E A, Wright Z M, Regan R C, Siedlecki C T, Bergman P J (2017) Retrospective evaluation of toceranib phosphate (Palladia®) toxicity in cats. Vet Comp Oncol 15(3), 710-717 PubMed DOI: 10.1111/vco.12211.
- Olmsted G A, Farrelly J, Post G S, Smith J (2017) Tolerability of toceranib phosphate (Palladia) when used in conjunction with other therapies in 35 cats with feline oral squamous cell carcinoma: 2009-2013. J Feline Med Surg 19(6), 568-575 PubMed DOI: 10.1177/1098612X16638118.
- Wiles V, Hohenhaus A, Lamb K, Zaidi B, Camps-Palau M, Leibman N (2017) Retrospective evaluation of toceranib phosphate (Palladia) in cats with oral squamous cell carcinoma. J Feline Med Surg 19(2),185-193 PubMed DOI: 10.1177/1098612X15622237.