Mupirocin
Synonym(s): Pseudominic acid
Introduction
Name
- Mupirocin.
Class of drug
- Antibacterial agent.
Description
Chemical name
- [2S-[2alpha(E),3beta,4beta,5alpha[2R*,3R*(1R*,2R*)]]]-9-[[3-methyl-1-oxo-4-[tetrahydro-3,4-dihydroxy-5-[[3-(2-hydroxy-1-methylpropyl)oxiranyl]methyl]-2H-pyran-2-yl]-2-butenyl]oxy]nonanoic acid.
Molecular formula
- C26, H44, O9.
Molecular weight
- 500.63.
Physical properties
- Crystalline.
Uses
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Administration
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Pharmacokinetics
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Precautions
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Withdrawal Periods
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Adverse Reactions
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
- Harbarth S et al (1999) Randomized, placebo-controlled, double-blind trial to evaulate the efficacy of mupirocin for eradicating carriage of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 43 (6) 1412-1416.
- Williford P M (1999) Opportunities for mupirocin calcium cream in the emergency department. J Emerg Med 17 (1) 213-220.
- Riu S et al (1998) Spontaneous rupture of polyurethane peritoneal catheter. A possible deleterious effect of mupirocin ointment. Nephrol Dial Transplant 13 (7) 1870-1871.
- Cookson B D (1998) The emergence of mupirocin resistance - a challenge to infection control and antibiotic prescribing practice. J Antimicrob Chemother 41 (1) 11-18.
- Goldfarb J (1995) New antimicrobial agents. Pediatr Clin North Am 42 (3) 717-735.
- Vizcaino-Alcaide M Jet al(1993) Efficacy of a broad-spectrum antibiotic (mupirocin) in an in vitro model of infected skin. Burns 19 (5) 392-295.
- Leyden J J (1992) Review of mupirocin ointment in the treatment of impetigo. Clin Pediatr (Phila) 31 (9) 549-553.
- Czarnecki D et al (1992) Prevention of post-excisional wound infections - a comparison of oral cephalexin with topical mupirocin and topical cetrimide-chlorhexidine cream. Int J Dermatol 31 (5) 359-360.
- Lamb Y J (1991) Overview of the role of mupirocin. J Hosp Infect 19 (Suppl. B) 27-30.
- Johnston C (1991) Topical 2% mupirocin versus 2% sodium fusidate ointment in the treatment of primary and secondary skin infections. J Am Acad Dermatol 24 (5-1) 797-798.
Other sources of information
- Tennant, B (1999) Small Animal Formulary. 3rd edn. British Small Animal Veterinary Association, UK. ISBN: 0 9052 1452 8.
- European Medicines Agency (online) Categorisation of Antibiotics for Use in Animals for Prudent and Responsible Use. Website: www.ema.europa.eu (pdf download).