Feline sarcoma virus
Synonym(s): Feline sarcoma virus, FeSV
Introduction
Classification
Taxonomy
- Family: Retrovirus.
- Type: Gammaretrovirus.
Etymology
- Retro because the viral RNA is reverse transcribed into DNA (proviral DNA).
Distribution
- Worldwide.
- Rare.
Significance
- Feline sarcoma viruses (FeSVs) are recombinant viruses that arise in cats persistently infected with FeLV.
- Recombinant viruses arise through FeLV recombining with host cellular genes.
- If reconstruction leads to the incorporation of a cellular oncogene, tumors or leukemias may develop.
- FeLV recombinant viruses incorporating cellular oncogenes are incapable of replication without the help of wild-type FeLV.
- There is no evidence of transmission between cats although experimental transmission has been demonstrated.
Active Forms
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Resting Forms
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Clinical Effects
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Diagnosis
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
Other sources of information
- Keller E T, Helfand S C (1994) Clinical management of soft-tissue sarcomas. In: Consultations in feline internal medicine 2. Ed John R. August. W B Saunders Co., Harcourt Brace Jovanovich, Inc. The Curtis Center, Independence Square West, Philadelphia, PA 19106. pp 3-12.
- Hardy W D Jr. (1987) Oncogenic viruses of cats: the feline leukemia and sarcoma viruses. In: Diseases of the Cat: Medicine and Surgery Ed Holzworth, J. W B Saunders Co., Harcourt Brace Jovanovich, Inc. The Curtis Center, Independence Square West, Philadelphia, PA 19106. pp 256-258.
Organization(s)
- Companion Animal Diagnostics, Veterinary Diagnostic Services. Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow, G61 1QH, Scotland. Tel: + 44 141 330 5777; Fax: + 44 141 330 5748; E-mail: companion@vet.gla.ac.uk .