Endocrinology: hypopituitary axis for GH production - diagram in Cats (Felis) | Vetlexicon
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Endocrinology: hypopituitary axis for GH production – diagram

ISSN 2398-2950

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Endocrinology: hypopituitary axis for GH production - diagram

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  1. In the normal animal growth hormone releasing hormone (GHRH) is produced by the hypothalamus and stimulates the anterior pituitary to produce GH.
  2. Growth hormone has a catabolic effect on tissues via antagonism of insulin actions but also stimulates hepatic production of insulin like growth factor (IGF) which has anabolic actions including protein synthesis.
  3. IGF has a negative feedback effect on the hypothalamus and the anterior pituitary to reduce further GH production.
  4. Increasing concentration of GH also reduces hypothalamic stimulation of the anterior pituitary for further GH production.
  5. Pituitary dwarfs  Congenital panhypopituitarism occur as a result of failure of GH production from the pituitary - as a result of hypothalamic failure.
  6. These animals are unable to grow normally.