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Zidovudine
Synonym(s): Azidothymidine, AZT
Introduction
Name
- Zidovudine, systemic.
Class of drug
- Nucleoside reverse transcriptase inhibitor antiviral.
Description
Chemical name
- 3′-Azido-3′-deoxythymidine.
Molecular formula
- C10H13N5O4.
Molecular weight
- 267.24.
Physical properties
- Synthetically derived, white crystalline powder.
- Soluble at 20 mg/mL in water.
- Human preparations are available in some localities as oral tablets, capsules, oral solution and injectable solution for infusion:
- Each 200 mg vial (10 mg/mL x 20 mL) concentrate for solution for infusion is a clear, colorless, sterile aqueous solution with a pH of 5.5.
- Injections must be diluted to <4mg/mL before administration.
Storage requirements
- Store oral dosage forms and undiluted solution for infusion at controlled room temperature (20-25°C/68-77°F). Once diluted in compatible fluids, the solution for infusion may be stored for 24 h at room temperature or 48 h in the refrigerator (2-8°C/35.6-46.4°F).
- Always check individual product guidelines and adhere to these.
Uses
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Administration
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Pharmacokinetics
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Precautions
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Adverse reactions
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Further Reading
Publications
Refereed papers
- Recent references from VetMedResource and PubMed.
- Hartmann K (2015) Efficacy of antiviral chemotherapy for retrovirus-infected cats: What does the current literature tell us? J Feline Med & Surg 17 (11), 925-939 PubMed.
Other sources of information
- ViiV Healthcare (2023) Retrovir® Package Insert. ViiV Healthcare, USA. Website: www.viivheatlhcare.com (pdf download) .
Organization(s)
- National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
- Veterinary Medicines Directorate (VMD) Product Information Database. Website: www.vmd.defra.gov.uk.
- VetMedux (online) Plumb’s. Website: www.plumbs.com.