Insulin: glucose ratio in Cats (Felis) | Vetlexicon
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Insulin: glucose ratio

ISSN 2398-2950

Contributor(s) :


  • Plasma concentrations of glucose Blood biochemistry: glucose, and insulin Insulin assay, are usually tightly linked.
  • Alterations in glucose result in rapid alteration of insulin to bring glucose back to normal range.



  • A diagnosis of insulinoma Insulinoma, is supported by demonstration of normal or high insulin levels in the presence of hypoglycemia.


Source of test material

Quantity of test material

  • 1 ml whole blood for each assay (insulin and glucose).

Sample collection technique

Step 1

  • Fast animal for 12 hours prior to testing.
  • Collect blood samples into fluoride oxalate and plain tube labeling sample with time and owner's name.
  • Ideally collect second set of samples at a different time.

Quality control


  • Label sequential samples with care. (Easy to mix up.)

Sample storage

  • Separate serum from sample for insulin assay prior to storage.
  • Store samples in a refrigerator prior to despatch.

Sample transport



  • Many commercial laboratories.

Result Data

Abnormal values

  • Insulinoma.

Further Reading


Refereed papers

  • Recent references from VetMedResource and PubMed.
  • Feldhahn J R et al (1999) The effect of interday variation and a short-term stressor on insulin sensitivity in clinically normal cats. J Fel Med Surg 1(4), 233-240.
  • Edwards D F (1986) Is it time to unamend the insulin glucose ratio? JAVMA, 951-953.
  • Knowlen G C & Schall W D (1984) The amended insulin glucose ration is it really better? JAAMA 185, 397-399.