Ingestion accidental or through treatment by owner.
Signs: vomiting, melena.
No adverse clinical signs or abnormal laboratory parameters if serum ibuprofen concentrations <31 ug/ml. Print off the owner factsheetIbuprofen and Naproxen toxicosisIbuprofen and Naproxen toxicosis to give to your client.
Care with gastric lavage Gastric lavage if evidence of GI inflammation or ulceration.
Cause a prostaglandin deficiency by inhibition of cyclo-oxygenases (COX).
Low safety margin as excreted slowly.
Low doses cause GI signs.
Higher doses also result in organ damage, particularly renal damage.
Readily absorbed from gastrointestinal tract, and highly bound by plasma proteins.
Interferes with prostaglandin synthesis.
Locally irritant to the gastrointestinal tract.
Reduces prostaglandin-mediated defense mechanisms in the stomach.
Suppresses protective prostaglandin-mediated vasodilation in the kidneys.
Toxic dose for dogs, 50 mg/kg with renal failure and death at 300 mg/kg. Corresponding doses for cats approximately half those for dogs.
Signs develop within 4-6 hours of acute intoxication.
Chronic therapy may also cause signs.
Renal failure may develop within 12 hours of massive dose.
Can be delayed up to 3-5 days at lower dose.
History of exposure to poison and appropriate clinical signs.