Ciclosporin in Cats (Felis) | Vetlexicon
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Ciclosporin

ISSN 2398-2950

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Synonym(s): Cyclosporine, Ciclosporin A, Cyclosporine A

Introduction

Name

  • Ciclosporin.

Class of drug

  • Immunosuppressive agent.

Description

Chemical name

  • Ciclosporin A.

Molecular formula

  • C62H111N11O12.

Physical properties

  • Available in the following formulations (not all licensed for use in cats):
    • Eye ointment.
    • Eye drops.
    • Capsules.
    • Solution for injection.
    • Solution for oral administration.

Storage requirements

  • <25°C/77°F.
  • Oral solution: a jelly-like formation may occur below 15°C/59°F which is however reversible at temperatures up to 25°C/77°F without affecting the quality of the product.

Uses

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Administration

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Pharmacokinetics

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Precautions

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Noli C & Scarampella F (2006) Prospective open pilot study on the use of ciclosporin for feline allergic skin disease. JSAP 47, 434-438.
  • Last R D, Suzuki, Y, Manning T Iet al (2004) A case of fatal systemic toxoplasmosis in a cat being treated with cyclosporin A for feline atopyVet Dermatol 15 (3), 194-198. WileyOnline
  • Mehl M L, Kyles A E, Craigmill A L et al (2003) Disposition of cyclosporine after intravenous and multi-dose oral administration in cats. .J Vet Pharmacol Ther 26 (5), 349. WileyOnline

Other sources of information

  • Novartis Pharmaceuticals UK Ltd (2024) Sandimmun Concentrate for Solution for Infusion 50 mg/mL (human authorized medicine). Website: www.medicines.org.uk.
  • Virbac UK (2024) Cyclavance 100 mg/mL Oral Solution for Cats and Dogs. Website: www.vmd.defra.gov.ukuk.virbac.com
  • Elanco (2023) Atopica 100 mg/mL Oral Solution for Cats and Dogs. Website: www.vmd.defra.gov.uk
  • Elanco (2023) Atopica Soft Capsules for Dogs, 10 mg, 25 mg, 50 mg, 100 mg. Website: www.vmd.defra.gov.uk
  • Allerton F (2023) Small Animal Formulary.11th edn. BSAVA, UK.
  • MSD Animal Health UK Limited (2021) Optimune 2 mg/g Eye Ointment for Dogs. Website: www.vmd.defra.gov.uk
  • Le Vet Beheer B.V (2018) Sporimune 100 mg/mL Oral Solution for Cats and Dogs. Website: www.vmd.defra.gov.uk
  • Regnier A & Ward D (1999) Clinical Pharmacology and Therapeutics. In: Veterinary Ophthalmology. 3rd edn. Ed Gelatt K Lippincott, Williams and Wilkins, USA.
  • Plumbs (online) VetMedux, USA. Website: www.plumbs.com.