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Blood biochemistry: alkaline phosphatase
Synonym(s): ALP, Serum alkaline phosphatase, SAP
Overview
- Number of isoenzymes produced in a range of tissues (liver, kidney, intestine, placenta).
- Increased plasma levels are derived from liver and bone.
- Good indicator of liver disease and cholestasis.
- Short half-life of ALP in the cat, therefore any rise likely to be significant.
Uses
Alone
- Cholestasis.
- Bone disease.
In combination
- Liver disease.
- Anticonvulsant induction Phenobarbital.
Sampling
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Tests
Methodologies
- Method and normal range may vary between laboratories.
- Electrophoretic or other separation method necessary to measure activity of individual isoenzymes.
Validity
Sensitivity
- Sensitive indicator of cholestasis or hyperadrenocorticism Hyperadrenocorticism, but not specific.
Technique intrinsic limitations
- Test results most significant when interpreted in conjunction with other laboratory results and clinical findings.
Result Data
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
Other sources of information
- Ettinger S J & Feldman E C (2000) Eds. Textbook of Veterinary Internal Medicine. 5th edn. W B Saunders & Co, USA.
- Kaneko J J, Harvey J W & Brass M L (1997) Eds. Clinical Biochemistry of Domestic Animals. 5th edn. Academic Press, USA.
- Duncan J R, Prasse K W & Mahaffey E A (1994) Veterinary Laboratory Medicine. Clinical Pathology. 3rd edn. Iowa University Press, USA.