felis - Articles
Buprenorphine
Synonym(s): Buprenorphine HCl, Simbadol, Zorbium
Introduction
Name
- Buprenorphine.
Class of drug
- Long-acting partial opioid antagonist-agonist.
- Controlled Substance (Schedule 3) Controlled drugs: legal requirements for storage, prescription and supply.
Description
Chemical name
- [5-alpha,7-alpha(S)]-17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-6,14-ethenomorphinan-7-methanol.
- 21-cyclopropyl-7-alpha-[(S)-1-hydroxy-1,2,2-trimethylpropyl]-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine.
Molecular formula
- C29H41NO4.
Physical properties
- Colorless, aqueous solution.
Storage requirements
- <25°C.
- Protect from light.
- Discard any solution remaining in opened vial after dose withdrawn.
Uses
Subscribe To View
This article is available to subscribers.
Try a free trial today or contact us for more information.
Administration
Subscribe To View
This article is available to subscribers.
Try a free trial today or contact us for more information.
Pharmacokinetics
Subscribe To View
This article is available to subscribers.
Try a free trial today or contact us for more information.
Precautions
Subscribe To View
This article is available to subscribers.
Try a free trial today or contact us for more information.
Withdrawal Periods
Subscribe To View
This article is available to subscribers.
Try a free trial today or contact us for more information.
Adverse Reactions
Subscribe To View
This article is available to subscribers.
Try a free trial today or contact us for more information.
Further Reading
Publications
Refereed papers
- Recent references from VetMedResource and PubMed.
- Robertson S A, Taylor P M & Sear J W (2003) Systemic uptake of buprenorphine by cats after oral mucosal administration.Vet Rec 152, 675-678.
- Dobbins S, Brown N O & Shofer F S (2002) Comparison of the effects of buprenorphine, oxymorphone hydrochloride and ketoprofen for post-operative analgesia after onychectomy or onychectomy and sterilization in cats. JAAHA 38 (6), 507-514.
- Skarda R T, Hubbell J A, Muir W W, Bednarski R M & Mason D E (1996) Sedation and anesthesia in dogs and cats with cardiovascular diseases. III. Ventilation, respiratory monitoring, treatment for postoperative pain. Schweiz Arch Tierheilkd 138 (6), 312-318. (In German)
- Piercy AD (1985) Use of buprenorphine hydrochloride. Vet Rec 117 (10), 256.
Other sources of information
- Based on Small Animal Formulary.Tennant B (1999) 3rd edn. BSAVA, UK. ISBN: 0 9052 1452 8.
- Plumb D C (1999) Veterinary Drug Handbook. 3rd edn. Iowa State University Press, USA. pp 85-87.
- Simbadol product insert. Website: www2.zoetisus.com/content/pages/products/cats/SIMBADOL-Resources/documents/simbadol-prescribing-information.pdf
- Simbadol frequently asked questions. Website: www.zoetisus.com/products/cats/simbadol/pdf/simbadol-faq.pdf
- Freedom of information summary, Zorbium. Website: animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/11847