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Hematology: basophil

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Overview

  • Basophils are small (8-15 µm) round cells (typically smaller than hererophils and eosinophils in the same blood film) that contain variable numbers of round basophilic (dark blue to purple) metachromatic cytoplasmic granules.
  • The nucleus is often obscured by granules, but when visible is non-lobed and slightly eccentric in position.
  • Species differences in basophil sizes occur. Lizards tend to have smaller basophils than those observed in chelonians and crocodiles.
  • Reptilian basophils most likely function in a manner similar to mammalian basophils by processing surface immunoglobulins and releasing histamine upon degranulation (based on cytochemical and ultrastructural studies).
  • Associated with parasitic and viral infections.

Uses

Alone

  • Useful to detect parasitic and viral infections.

In combination

  • With other red and white blood cell parameters as part of routine hematological screen.

Sampling

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Tests

Availability

  • Widely available at commercial laboratories. Check expertise in reptile hematology before sample(s) are sent.
  • May be performed in practice.

Result Data

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Troiano J C, Gould E G & Gould I (2008) Hematological reference intervals in argentine lizard Tupinambis merianae (Sauria - Teiidae). Comp Clin Pathol 17 (2), 93-97 Academia.
  • Harr K E, Alleman A R, Dennis P M, Maxwell L K et al (2001) Morphologic and cytochemical characteristics of blood cells and hematologic and plasma biochemical reference ranges in green iguanas. JAVMA 218 (6), 915-921 PubMed.

Other sources of information

  • Campbell T (2015) Peripheral Blood in Reptiles. In: Exotic Animal Hematology and Cytology. 4th edn. Wiley-Blackwell. pp 67-87.
  •  Saint Girons M C (1970) Morphology of the Circulating Blood cCll. In: Biology of the Reptila. Eds: Gans C & Parsons T. Academic Press, USA.