reptile - Articles
Pethidine
Introduction
Name
- Pethidine.
- Meperidine.
Class of drug
- Synthetic opioid analgesic of the phenylpiperidine class.
- u-opioid receptor agonist, with some activity on k and d receptors.
Description
Chemical name
- Ethyl 1-methyl-4-phenyl-4-piperidinecarboxylate (IUPAC name).
Molecular formula
- C15H21NO2.
Molecular weight
- 247.3364.
Physical properties
- Fine white crystalline powder.
- Very soluble in water.
- pH 3.5-6 in commercial injectable forms.
Storage requirements
- Tablets and infection should be stored in tightly closed containers protected from light, and not allowed to freeze.
- Stable at room temperature.
- Schedule 2 controlled drug in the UK - thus subject to strict storage, prescription, dispensing, destruction and record keeping requirements.
Uses
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Administration
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Pharmacokinetics
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Precautions
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Withdrawal Periods
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Adverse Reactions
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
- Sladky K & Mans C (2012) Clinical analgesia in reptiles. J Exotic Pet Med 21 (2), 158-167 SciDirect.
- Wambugu S N, Towett P K, Kiama S G et al (2010) Effects of opioids in the formalin tests in the Speke’s hinged tortoise (Kinixys spekii). J Vet Pharmacol Therap 33 (4), 347-351 WileyOnline.
Other sources of information
- Plumb D (2015) Plumb’s Veterinary Drug Handbook. 8th edn. Wiley Blackwell, USA. pp 1296.
- Girling S J & Raiti P (2004) BSAVA Manual of Reptiles. BSAVA, UK. pp 383.
Organisation(s)
- National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.