ferret - Articles
Musculoskeletal lymphoma
Synonym(s): Lymphoma, myeloma and leukemia of the bone
Introduction
- Cause: unknown.
- Signs: weaknes, lethargy, posterior ataxia and paresis, anorexia, loss of weight/condition.
- Diagnosis: hematology, serum chemistry, radiography, spleen biopsy.
- Treatment: surgical removal.
- Prognosis: poor for skeletal lesions.
Presenting signs
- Weakness.
- Lethargy.
- Posterior ataxia and paresis.
- Anorexia.
- Weight and condition loss.
Pathogenesis
Etiology
- Unknown.
Pathophysiology
- Lymphosarcoma as a generalized disease and may invade the skeleton.
- Lymphoma may metastasize particularly to the vertebra.
- The invading tumor causes osteolytic lesions.
- One report found a lobulated firm, light tan mass occupying the body of the lumbar vertebra:
- The mass had invaded the bone marrow, adjacent bone, muscles and vertebral canal.
- The bone was fractured Fractures.
- The mass was a poorly demarcated and unencapsulated mass of neoplastic plasma cells.
- The adjacent bone was necrotic and in some areas replaced by fibrous connective tissue.
- A cystic bone lesion in the proximal humerus with a non-supporting lameness of the foreleg was also reported.
- Lytic masses have been noted in various bones.
Diagnosis
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Treatment
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Prevention
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Outcomes
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
- Suran J N & Wyre N R (2013) Imaging findings in 14 domestic ferrets (Mustela putorius furo) with lymphoma. Vet Radiol Ultrasound 54 (5), 522-531 PubMed.
- Eshar D, Wyre N R, Griessmyr P, Durham A & Hoots E (2010) Diagnosis and treatment of myelo-osteolytic plasmablastic lymphoma of the femur in a domestic ferret. JAVMA 237 (4), 407-414 PubMed.
- Marks A L, Gaschen L, Tully Jr T N, Grasperge B J, Rich G A (2010) What is your diagnosis? Plasma Cell Neoplasia. JAVMA 237 (9), 1033-1034 PubMed.