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Hematology: monocyte

ISSN 2398-2985


Synonym(s): Mononuclear phagocytes

Overview

  • Monocytes are usually the largest cells present on the blood film. The nucleus may vary from round to lobed. The cytoplasm is moderately abundant, light blue-gray in color and may be vacuolated and with fine azurophilic granules.
  • Monocytes circulate in the blood briefly (approximately one day) → enter the tissues → transform into macrophages → do not re-enter the circulation. The ratio of circulating monocytes to macrophages is ~1:400. Therefore, it can be considered that monocytes in peripheral blood are immature cells.
  • The mononuclear phagocytizing system (bone marrow precursors, monocytes and macrophages) phagocytizes and destroys microorganisms and particulate material (foreign bodies, tissue and cellular debris). It also interacts with lymphocytes in immune reactions, produces interferon and regulates hematopoiesis.

Uses

Alone

  • Measuring circulating monocytes can give an indication of infection and inflammation, particularly chronic ones.

In combination

  • With differential white blood cell count.

Sampling

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Tests

Methodologies

  • Differential white blood cell count.

Result Data

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Hein J, Spreyer F, Sauter-Louis C et al (2012) Reference ranges for laboratory parameters in ferrets. Vet Rec 171, 218 PubMed.

Other sources of information

  • Mayer J & Donnelly T M (2013) Clinical Veterinary Advisor: Birds and Exotic Pets. Elsevier, USA. pp 752.
  • Campbell T W & Ellis C K (2007) Avian and Exotic Hematology and Cytology. 3rd edn. Wiley-Blackwell. ISBN: 978-0813818115.
  • Fudge A M (1999) Laboratory Medicine. Avian and Exotic Pets. W B Saunders Co. ISBN: 0721 676 790