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Blood biochemistry: gammaglutamyl transferase

ISSN 2398-2985


Synonym(s): GGT, Gammaglutamyl transpeptidase, ⍺-Glutaryltransferase

Overview

  • Gammaglutamyl transferase (GGT) is a membrane-associated enzyme, produced in liver, pancreas and kidney.
  • Liver GGT is found primarily in the epithelium of the bile ducts.
  • The hepatobiliary system is therefore the primary source of serum GGT and is more diagnostic for hepatobiliary disease than for hepatocellular damage.
  • In addition to biliary GGT, which is the main source of GGT, significant levels of renal epithelial GGT can be found in the urine.
  • Urine GGT levels may be increased in cases of renal damage; in addition, plasma GGT may also be increased in these cases, but this is rare.

Uses

In combination

  • Hepatobiliary disease.
  • Renal damage (increase in urine GGT levels as well).
  • In other species abnormal values of GGT have been seen associated with cholestatic disorders, liver damage, biliary obstruction or damage (neoplasia, inflammation, cholelithiasis, intrahepatic or extrahepatic cholestasis or other biliary compromise).

Sampling

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Tests

Methodologies

  • Varies between laboratories, usually colorimetric method based on enzymatic reaction.

Availability

  • Widely available.

Validity

Predictive value

Technique intrinsic limitations

  • Test results most significant in conjunction with other laboratory results and clinical findings.

Result Data

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Hein J, Spreyer F, Sauter-Louis C et al (2012) Reference ranges for laboratory parameters in ferrets. Vet Rec 171, 218 PubMed.
  • Hauptman K, Tichy F & Znotek Z (2001) Clinical diagnostics of hepatopathies in small mammals: evaluation of importance of individual methods. Acta Vet Brno 70, 297-311.

Other sources of information

  • Phelps C A & Mayer J (2013) Gammaglutamyl Transferase. In: Clinical Veterinary Advisor Birds and Exotic Pets. Eds: Mayer J & Donnelly T M. Eslevier, USA. pp 617-618.