ferret - Articles
Blood biochemistry: aspartate aminotransferase
Synonym(s): AST, Serum AST, SAST, Glutamic oxalo-acetic transaminase, GOT, Serum GOT, SGOT
Overview
- Highest activity levels are in liver, cardiac muscle, red blood cells and skeletal muscle.
- Less specific than ALT for liver damage in ferrets.
Uses
Alone
- Little use on its own.
In combination
- Skeletal muscle damage.
- Liver damage (hepatocellular necrosis).
- Cardiac ischemia.
- Always combine with CK, ALT, AP and bilirubin.
Sampling
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Tests
Methodologies
- Method and normal range may vary between laboratories.
Availability
- Widely available.
Validity
Sensitivity
- Significant less sensitivity for liver damage in ferrets when compared to ALT.
Specificity
- Little specificity, as it is also found in skeletal muscles and cardiac muscle.
Technique intrinsic limitations
- Results only significant when interpreted in conjunction with other laboratory tests and clinical findings.
Result Data
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Further Reading
Publications
Refereed Papers
- Recent references from PubMed and VetMedResource.
- Li T, Yoshizaki S, Kataoka M et al (2017) Genetic and physicochemical analyses of a novel ferret hepatitis E virus, and clinical signs of infection after birth. Infection Genetics and Evolution 51, 153-159 PubMed.
- Hein J, Spreyer F, Sauter-Louis C et al (2012) Reference ranges for laboratory parameters in ferrets. Vet Rec 171, 218 PubMed.
Other sources of information
- Fox J G & Marini R P (2014) Eds. Biology and Diseases of the Ferret. 3rd edn. Wiley Blackwell, USA. pp 835.
- Mayer J & Donnelly T M (2013) Clinical Veterinary Advisor: Birds and Exotic Pets. Elsevier, USA. pp 752.
- Hoefer H L & Bell J A (2004) Gastrointestinal diseases. In: Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery. Eds: K E Quesenberry & J W Carpenter. Elsevier. pp 25-40.