Epitheliotropic lymphoma in Ferrets | Vetlexicon
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Epitheliotropic lymphoma

ISSN 2398-2985

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Synonym(s): Cutaneous epitheliotropic lymphoma, Mycosis fungoides, Cutaneous T cell lymphoma

Introduction

  • Cause: neoplastic infiltration of the epidermis and adnexal structures, T cell neoplasm.
  • Signs: multifocal to generalized alopecia, erythema, epithelial scaling and skin thickening, discrete nodules, ulceration, variable pruritus. Systemic signs if metastatic disease present.
  • Diagnosis: histopathology, immunohistochemistry.
  • Treatment: prednisolone, some reports of chemotherapy protocols in ferrets.
  • Prognosis: guarded.

Presenting signs

  • Progressive alopecia.
  • Scaling or crusting.
  • Erythema.
  • Skin nodules.
  • Ulcerations.

Age predisposition

  • Older animals more commonly affected.

Breed/Species predisposition

  • Rarely reported in ferrets.

Cost considerations

  • Diagnostics may be costly, especially immunohistochemistry.

Special risks

  • Anesthesia required for skin biopsies.

Pathogenesis

Etiology

  • Unknown.

Predisposing factors

General

  • Unknown.
  • Chronic inflammation/antigenic stimulation proposed as a risk factor in humans and dogs but not proven.

Pathophysiology

  • Neoplastic infiltration of epidermis and adnexal structures with T lymphocytes.

Timecourse

  • Progressive over weeks to months.

Epidemiology

  • Rare incidence.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Rosenbaum M R, Affolter V K, Usborne A L & Beeber N L (1996) Cutaneous epitheliotropic lymphoma in a ferret. JAVMA 209 (8), 1441-1444 PubMed.

Other sources of information

  • Orcutt C & Tater K (2012) Dermatologic Diseases. In: Ferrets, Rabbits and Rodents. 3rd edn. Eds: Quesenberry K E & Carpenter J W. Saunders, USA. pp 122-131.