equis - Articles
Bretylium
Introduction
Name
- Bretylium tosilate (INN).
- Bretylium tosylate (USP).
Class of drug
- Class III antiarrhythmic agent.
- Quaternary ammonium compound.
Description
Chemical name
- (2-bromophenyl)methyl-ethyl-dimethylazanium;4-methylbenzenesulfonate.
- N-(o-bromobenzyl)-N-ethyl-N,N-dimethylammonium tosylate.
Molecular formula
- C18H24BrNO3S.
Molecular weight
- 414.4 g/mol.
Physical properties
- White, crystalline powder.
Storage requirements
- At room temperature.
Uses
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Administration
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Pharmacokinetics
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Precautions
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Adverse reactions
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
- Thind M, Sullivan R M, Williams R N, Kowey P R. (2000) Bretylium a class III antiarrhythmic, returns to the market. Am J Cardiol 133, 77-80 PubMed.
Other sources of information
- Sage A & Mogg T D (2010) Pharmacology of Drugs Used to Treat Cardiac Disease. In: Cardiology of the Horse. 2nd edn. Eds: Marr C M & Bowen I M. Elsevier, UK. pp 75-80. ISBN: 978-0-7020-2817-5.
- Schwarzwald C C (2009) Cardiovascular Pharmacology. In: Current Therapy in Equine Medicine. Eds: Robinson N E & Sprayberry K A. 6th edn. Saunders, USA. pp 182-191.
Organization(s)
- National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
- Veterinary Medicines Directorate (VMD) Product Information Database. Website: www.vmd.defra.gov.uk.