equis - Articles
Tiletamine with zolazepam
Introduction
Name
- Tiletamine/zolazepam combination.
Only available as 1:1 combinations - Telazol® (US) and Zoletial® (Europe).
Class of drug
- Tiletamine - phencylidine derivative; dissociative anesthetic; NMDA-receptor antagonist.
- Zolazepam - benzodiazepine; muscle relaxant; modulation of chloride ion transport following binding of the GABAA receptor.
Description
Chemical name
- Tiletamine - 2-ethylamino-2-2(2-thienyl) cyclohexanone.
- Zolazepam - 4-(2-fluorophenyl)-1,3,8-trimethyl-6,8-dihydrophyrazolo[3,4-e][1,4]diazepin-7(1H)-one.
Molecular formula
- Tiletamine - C12H17NOS.
- Zolazepam - C15H15FN4O.
Molecular weight
- Tiletamine - 223.34 g.
- Zolazepam - 286.304 g.
Physical properties
- Yellow, crystalline freeze dried solid.
- 571 mg active drug as a 1:1 ratio per vial.
Storage requirements
- Store in a cool place below 30°C.
- Once reconstituted can be kept at 4°C for 8 days with retention of 90% efficacy (Zoletil®).
Uses
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Administration
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Pharmacokinetics
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Precautions
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Withdrawal Periods
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Adverse Reactions
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
- Cuvelliez S, Rosseel G & Blais D (1995) Intravenous anesthesia in the horse: comparison of xylazine-ketamine and xylazine-tiletamine-zolazepam combinations. Can Vet J 36 (10), 613-618 PubMed.
- Matthews N S & Myers M M (1993) The use of tiletamine-zolazepam for darting feral horses. J Eq Vet Sci 13 (5), 264-267.