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Firocoxib


Introduction

Name

  • Firocoxib.

Class of drug

  • Non-stroidal anti-inflammatory drug.
  • Coxib class.

Description

  • Supportive therapy.
  • Gastroprotectants.

Uses

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Administration

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Pharmacokinetics

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Precautions

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Withdrawal Periods

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Knych H K et al (2014) Detection and pharmacokinetics of three formulations of firocoxib following multiple administrations to horses. Equine Vet J 46 (6), 734 PubMed
  • Hilton H G et al (2011) Distribution of flunixin meglumine and firocoxib into aqueous humor of horses. J Vet Intern Med 25 (5), 1127-1133 PubMed.
  • Koene M et al (2010) Field trial validation of the efficacy and acceptability of Firocoxib, a highly selective COX-2 inhibitor, in a group of 96 lame horses. J Eq Vet Sc 30 (5), 237-243 VetMedResource.
  • Back W, MacAllister C G & van Heel M C V et al (2009) The use of force plate measurements to titrate the dosage of a new COX-2 inhibitor in lame horses.Equine Vet J 41 (3), 309-312 PubMed.
  • Cook V L, Meyer C T, Campbell N B & Blikslager A T (2009) Effect of firocoxib or flunixin meglumine on recovery of ischemic-injured equine jejunum. Am J Vet Res 70 (8), 992-1000 PubMed.
  • Dutton D W, Lashnits K J & Wegner K (2009) Managing severe hoof pain in a horse using multimodal analgesia and a modified composite pain scale. Equine Vet Educ 21 (1), 37-43 Wiley.
  • Doucet M Y, Bertone A L, Hendrickson D et al (2008) Comparison of efficacy and safety of paste formulations of firocoxib and phenylbutazone in horses with naturally occurring osteoarthritis. JAVMA 232 (1), 91-97 PubMed.
  • Letendre L T, Tessman R K, McClure S R et al (2008) Pharmacokinetics of firocoxib after administration of multiple consecutive daily doses to horses. Am J Vet Res 69 (11), 1399-1405 PubMed.
  • McConnico R S, Morgan T W, Williams C C, Hubert J D & Moore R M (2008) Pathophysiologic effects of phenylbutazone on the right dorsal colon in horses. Am J Vet Res 69 (11), 1496-1505 PubMed
  • Kvaternick V, Pollmeier M, Fischer J et al (2007) Pharmacokinetics and metabolism of orally administered Firocoxib, a novel second-generation coxib, in horses. J Vet Pharm Ther 30 (3), 208-217 PubMed.

Other sources of information

  • Plumb D C (2011) Veterinary Drug Handbook. 7th edn. Wiley-Blackwell, USA.
  • Hanson P D & Maddison J E (2008) Nonsteroidal anti-inflammatory drugs and chondroprotective agents. In: Small Animal Clinical Pharmacology. Eds: Maddison J E & Page S W & Church D B Saunders Elsevier, USA. pp 287-309.
  • Equioxx® (firocoxib) product information - Website: www.equioxx.com.