Dimethyl sulfoxide
Synonym(s): DMSO
Introduction
Name
- Dimethyl sulfoxide.
Class of drug
- Highly polar organic liquid that is used widely as a chemical solvent and a free radical scavenger.
Description
Chemical name
- Methylsulfinylmethane.
Molecular formula
- (CH3)2SO.
Molecular weight
- 78.14.
Physical properties
- Colorless, slightly oily liquid.
Storage requirements
- Store at room temperature and protect from exposure to moisture as DMSO is a very hygroscopic liquid.
Uses
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Administration
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Pharmacokinetics
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Precautions
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Withdrawal Periods
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Adverse Reactions
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
- Soma L R, Robinson M A, You Y et al (2018) Pharmacokinetics, disposition, and plasma concentrations of dimethyl sulfoxide (DMSO) in the horse following topical, oral, and intravenous administration. J Vet Pharmacol Ther 41 (3), 384-392 PubMed.
- Schleining J A & Reinertson E L (2007) Evidence for dimethyl sulfoxide (DMSO) use in horses. Part 2: DMSO as a parenteral anti-inflammatory agent and as a pharmacological carrier. Equine Vet Educ 19 (11), 598-599 WileyOnline.
- Schleining J A & Reinertson E L (2007) Evidence for dimethyl sulphoxide (DMSO) use in horses. Part 1: DMSO as a topical and intra-articular anti-inflammatory agent. Equine Vet Educ 19 (10), 545-546 WileyOnline.
- Smith C L, MacDonald M H, Tesch A M & Willits N H (2000) In vitro evaluation of the effect of dimethyl sulfoxide on equine articular cartilage matrix metabolism. Vet Surg 29 (4), 347-357 PubMed.
Other sources of information
- Plumb DC (2018) Plumb’s Veterinary Drug Handbook, Wiley Blackwell, USA. Online version at https://app.plumbs.com.
- Cole C, Bentz B, Maxwell L (2014) Equine Pharmacology, Wiley Blackwell, USA.
Organisation(s)
- National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.