equis - Articles
Dexmedetomidine
Introduction
Name
- Dexmedetomidine hydrochloride.
Class of drug
- Alpha-2 adrenergic agonist.
- Enantiomeric preparation of medetomidine consisting of the dextro-rotary isomer only.
- Perceived advantages are:
- Levo-rotatory isomer does not need to be metabolised.
- Analgesic duration may be prolonged (in dogs).
- Cardiovascular effects appear to be of shorter duration in ponies compared with equipotent doses of medetomidine.
Uses
Subscribe To View
This article is available to subscribers.
Try a free trial today or contact us for more information.
Administration
Subscribe To View
This article is available to subscribers.
Try a free trial today or contact us for more information.
Pharmacokinetics
Subscribe To View
This article is available to subscribers.
Try a free trial today or contact us for more information.
Precautions
Subscribe To View
This article is available to subscribers.
Try a free trial today or contact us for more information.
Withdrawal Periods
Subscribe To View
This article is available to subscribers.
Try a free trial today or contact us for more information.
Adverse Reactions
Subscribe To View
This article is available to subscribers.
Try a free trial today or contact us for more information.
Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
- Gazalo-Marcilla M et al (2013) Effects of a constant-rate infusion of dexmedetomidine on the minimal alveolar concentration of sevoflurane in ponies. Equine Vet J 45 (2), 204-208 PubMed.
- Auckburally A & Flaherty D (2011) Use of supplemental intravenous anaesthesia/analgesia. In Pract 33 (7), 334-339.
- Marcilla M G et al (2010) Cardiopulmonary effects of two constant rate infusions of dexmedetomidine in isoflurane anaesthetized ponies. Vet Anaes Analg 37, 311-321 PubMed.
- Valverde A et al (2010) Comparison of cardiovascular function and quality of recovery in isoflurane-anaesthetised horses administered a constant rate infusion of lidocaine or lidocaine and medetomidine during elective surgery. Equine Vet J 42 (3), 192-199 PubMed.
- Bettschart-Wolfensberger R & Larenza M P (2007) Balanced anesthesia in the equine. Clin Tech Eq Pract 6 (2), 104-110.
- Ringer S K et al (2007) A clinical comparison of two anaesthetic protocols using lidocaine or medetomidine in horses. Vet Anaesth Analg 34 (4), 257-268 PubMed.
- Kalchofner K S et al (2006) Clinical assessment of anesthesia with isoflurane and medetomidine in 300 equidae. Pferdeheilkunde 22 (3), 301.
- Bettschart-Wolfensberger R (2005) Cardiopulmonary effects and pharmacokinetics of i.v. dexmedetomidine in ponies. Equine Vet J 37 (1), 60-64 PubMed.
- Bettschart-Wolfensberger R et al (2003) Medetomidine-ketamine anaesthesia induction followed by medetomidine-propofol in ponies: infusion rates and cardiopulmonary side effects. Equine Vet J 35 (3), 308-313 PubMed.
- Bettschart-Wolfensberger R et al (1999) Cardiopulmonary effects of a two hour medetomidine infusion and its antagonism by atipamezole in horses and ponies. J Vet Anaesthesia 26, 8-12.
- Bettschart-Wolfensberger R et al (1999) Pharmacokinetics of medetomidine in ponies and elaboration of a medetomidine infusion regime which provides a constant level of sedation. Res Vet Sci 67 (1), 41-46 PubMed.