equis - Articles
Atipamezole
Introduction
Name
- Atipamezole hydrochloride.
Class of drug
- Apha-2 adrenergic antagonist.
Description
Chemical name
- 4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole.
Molecular formula
- C14H16N2.
Molecular weight
- 212.290 g.
Physical properties
- Clear colorless solution for injection available as a 5 mg/ml concentration.
- Contains methylparahydroxybenzoate as a preservative.
Storage requirements
- Do not store >25°C.
- Protect from light.
Uses
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Administration
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Pharmacokinetics
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Precautions
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Withdrawal Periods
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Adverse Reactions
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
- Di Concetto S, Archer M R, Sigurdsson S F et al (2007) Atipamezole in the management of detomidine overdose in a pony. Vet Anaes Analg 34, 67-69 PubMed.
- Hubbell J A E & Muir W W (2006) Antagonism of detomidine sedation in the horse using intravenous tolazoline or atipamezole. Equine Vet J 38, 238-241 PubMed.
- Bettschart-Wolfensberger R, Clarke K W, Vainio O et al (1999) Pharmacokinetics of medetomidine in ponies and elaboration of a medetomidine infusion regime which provides a constant level of sedation. Res Vet Sci 67, 41-46 PubMed.
- Buchner H H, Kubber P, Zohmann E et al (1999) Sedation and antisedation as tools in equine lameness examination. Eq Vet J Supp 30, 227-230 PubMed.
- Ramseyer B, Schmucker N, Schatzmann U et al (1998) Antagonism of detomidine sedation with atipamezole. J Vet An 25, 47-51.
- Matthews N S, Petrini K R & Wolff P L (1995) Anesthesia of Przewalskis Horses (Equus Przewalskii przewalskii) with medetomidine/ketamine and antagonism with atipamezole. J Zoo Wild Med 26, 231-236.
- Luna S P, Beale N J & Taylor P M (1992) Effects of atipamezole on xylazine sedation in ponies. Vet Rec 130 (13), 268-271 PubMed.
- Raekallio M, Vainio O & Karjalainen J (1990) The influence of atipamezole on the cardiovascular effects of detomidine in horses. J Ass Vet Anaesth 17, 50-53 PubMed.