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Amikacin
Synonym(s): Amikacin sulfate
Introduction
In the UK, Amikacin is classified as category C (Caution) by the European Medicines Agency (EMA).
Name
- Amikacin.
Class of drug
- Aminoglycoside antibacterial Therapeutics: aminoglycosides.
Description
Chemical name
- (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide.
Molecular formula
- C22H43N5O13.
Molecular weight
- 585.6.
Physical properties
- White crystalline powder.
Storage requirements
- Store at room temperature.
- The solution becomes light straw-colored during storage, but this does not indicate a loss of potency.
Uses
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Administration
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Pharmacokinetics
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Precautions
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Withdrawal Periods
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Adverse Reactions
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
- Pezzanite L, Chow L, Hendrickson D et al (2021) Evaluation of intra-articular amikacin administration in an equine non-inflammatory joint model to identify effective bactericidal concentrations while minimizing cytotoxicity. Front Vet Sci 8, 676774 PubMed.
- Dahan R, Oreff G L, Tatz A J et al (2019) Pharmacokinetics of regional limb perfusion using a combination of amikacin and penicillin in standing horses. Can Vet J 60, 294-299 PubMed.
- Pinto N, Schumacher J, Taintor J, Degraves F, Duran S & Boothe D (2011) Pharmacokinetics of amikacin in plasma and selected body fluids of healthy horses after a single intravenous dose. Equine Vet J 43 (1), 112-116 PubMed.
- Magdesian K G et al (2004) Pharmacokinetics of a high dose of amikacin administered at extended intervals in neonatal foals. Am J Vet Res 65 (4), 473-479 PubMed.
Other sources of information
- Plumb D C (2018) Plumb’s Veterinary Drug Handbook. Wiley Blackwell, USA. Online version: https://app.plumbs.com.
- Cole C, Bentz B & Maxwell L (2014) Equine Pharmacology. Wiley Blackwell, USA.
- Giguère S, Prescott J F & Dowling P M (2013) Eds Antimicrobial Therapy in Veterinary Medicine, 5th ed. Wiley Blackwell, USA.
Organisation(s)
- National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
- European Medicines Agency (online) Categorisation of Antibiotics for Use in Animals for Prudent and Responsible Use. Website: www.ema.europa.eu (pdf download).