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CSF: creatine kinase
Synonym(s): Creatinine kinase, CK
Overview
- An isoenzyme specific to the brain: increases in the cerebrospinal fluid (CSF), along with some other enzymes, in central nervous system (CNS) disease.
Uses
Alone
- Sensitive indicator of CNS injury or altered permeability of blood-brain barrier.
In combination
- With other biochemical measures and cytology CSF: cytology .
Sampling
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Tests
Methodologies
- Standard enzymatic method.
Validity
Sensitivity
- The sensitivity of CSF [CK] is not sufficient for diagnosis of a specific disease.
Specificity
- The specificity of CSF [CK] is not sufficient for diagnosis of a specific disease.
Result Data
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
- Johnson P J & Constantinescu G M (2000) Collection of cerebrospinal fluid in horses. Equine Vet Educ 12, 7-12.
- Johnson P J & Constantinescu G M (2000) Analysis of cerebrospinal fluid in horses. Equine Vet Educ 12, 13-17.
- Furr M O & Tyler R D (1990) Cerebrospinal fluid creatine kinase activity in horses with central nervous system disease - 69 cases (1984-1989). JAVMA 197 (2), 245-248.
Other sources of information
- Coles E H (1980) Veterinary Clinical Pathology. 3rd edn. WB Saunders Co, USA. (Review on CSF enzymology).