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Amlodipine
Introduction
Name
- Amlodipine besylate.
Class of drug
- Third generation dihydropyridine .
- Calcium-channel blocker.
Description
Chemical name
- (RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate.
Molecular formula
- C20H25ClN2O5
Molecular weight
- 408.879
Storage requirements
- Amodip 1.25 mg chewable tablets for cats:
- Do not store above 30°C.
- Shelf life of the veterinary medicinal product as packaged for sale: 30 months.
- Shelf life of halved tablets: 24 hours.
- Any unused half tablets should be returned to the blister pack.
Uses
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Administration
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Pharmacokinetics
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Precautions
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Withdrawal Periods
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Adverse Reactions
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Further Reading
Publications
Refereed papers
- Recent references from VetMedResource and PubMed.
- Huhtinen M, Derr�� G, Renoldi H J et al (2015) Randomized placebo-controlled clinical trial of a chewable formulation of amlodipine for the treatment of hypertension in client-owned cats.J Vet Intern Med 29 (3), 786-793 PubMed.
- Helms S R (2007) Treatment of Feline Hypertension With Transdermal Amlodipine: A Pilot Study. JAAHA 43 (3), 149-156 PubMed.
- Jepson R E, Elliott J, Brodbeld D, Syme H M (2007) Effect of control of systolic blood pressure on survival in cats with systemic hypertension. J Vet Intern Med 21, 402-409 PubMed.
- Snyder P S, Sadek D, Jones G L (2001) Effect of amlodipine on echocardiographic variables in cats with systemic hypertension. J Vet Intern Med 15 (1), 52-56 PubMed.
- Elliott J, Barber PJ, Syme H M, Rawlings J M & Markwell P J (2001) Feline hypertension: clinical findings and response to antihypertensive treatment in 30 cases. J Small Anim Pract 42 (3), 122-129 PubMed.
- Snyder P S (1998) Amlodipine: a randomized, blinded, clinical trial in 9 cats with systemic hypertension. J Vet Intern Med 12,157-162 PubMed.
Other sources of information
- Bijsmans E S, Jepson R E, Syme H M, Elliott J, Pelligand L (2015) Measurement of plasma amlodipine concentration using LC/MS/MS at the point of blood pressure control in hypertensive cats (abstract). J Vet Intern Med 29 (4), 1224 (ACVIM Forum Abstract).
- Small Animal Formulary. Tennant, Bryn (2014) 8th edn. BSAVA, UK.
- Bijsmans E S, Jepson R E, Syme H M & Elliott J (2014) The efficacy of amlodipine besylate to control hypertension in cats with CKD (abstract). BSAVA Congress Proceedings.