felis - Articles
Aglepristone
Synonym(s): RU 534
Introduction
Name
- Aglepristone.
Class of drug
- Progesterone receptor antagonist.
Description
Chemical name
- (8S,11R,13S,14S,17R)-11-(4-dimethylaminophenyl)-17-hydroxy-13-methyl-17-[(Z)-prop-1-enyl]-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
Molecular formula
- C29H37NO2
Molecular weight
- 431.60958
Physical properties
- Clear yellow oily solution.
Storage requirements
- Shelf life of 3 years.
- Once opened must be used within 28 days and discarded if discoloration occurs.
- As the available veterinary formulation contains no antibacterial preservative, swab the opening's membrane with suitable disinfectant each time before withdrawing the dose to be administered.
- Protect the bottle from light.
Uses
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Administration
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Pharmacokinetics
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Precautions
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Withdrawal Periods
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Adverse Reactions
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
- Georgiev P, Bostedt H, Goericke-Pesch S, Dimitrov M, Petkov P, Stojanthev K, Tsoneva V, Wehrend A (2010) Induction of abortion with aglepristone in cats on day 45 and 46 after mating. Reprod Domest Anim 45 (5), e161-167 PubMed.
- Goericke-Pesch S, Plamen, Georgiev P (2010) Prevention of pregnancy in cats using aglepristone on days 5 and 6 after mating. Theriogenology 74 (2), 304-310 PubMed.
- Jurka P, Max A (2009)Treatment of fibroadenomatosis in 14 cats with aglepristone - changes in blood parameters and follow-up. Vet Rec 165 (22), 657-660 PubMed.
- Nak D, Nak Y, Tuna B (2009) Follow-up examinations after medical treatment of pyometra in cats with the progesterone-antagonist aglepristone. JFMS 11(6), 499-502 PubMed.
- Favre R N, Gimenez F, Stornelli M C, Tittarelli C M, Savignone C A, de la Sota R L, Sternelli M A (2007) Induction of abortion in queens by administration of aglepristone (Alizin): Preliminary results. Theriogenology 68, 492-518; abstr.014.
- Fieni F, Martal J, Marnet P G, Siliart B, Guittot F (2006) Clinical, biological and hormonal study of mid-pregnancy termination in cats with aglepristone. Theriogenology 66 (6-7), 1721-1728. Epub 2006 Mar 24. Erratum In: Theriogenology 67 (7), 1305 PubMed.
- Georgiev P & Wehrend A (2006) Mid-gestation pregnancy termination by the progesterone antagonist aglepristone in queens.Theriogenology 65 (7), 1401-1406 PubMed.
- Georgiev P, Wehrend A, Dimitrov M, Vasilev N, Yotov S, Bostedt H (2006) Effect of progesterone receptor antagaonist aglepristone administered on days 5 and 6 after mating in queens.Reprod Domest Anim 41 (Suppl 1), 1-41 (abstr).
- Meisl D, Hubler M, Arnols S (2003) Treatment of fibroepithelial hyperplasia (FEH) of the mammary gland in the cat with progesterone antagonist aglepristone (Alizine). Schweiz Arch Tierheilkd 145 (3), 130-136 PubMed.
- Goerlinger S, Kooistra H S, van den Broek A, Okkens A C (2002) Treatment of fibroadenomatous hyperplasia in cats with aglepristone. J Vet Intern Med 16 (6), 710-713.
- Wehrend A, Hospes R, Gruber A D (2001)Treatment of feline mammary fibroadenomatous hyperplasia with a progesterone-antagonist. Vet Rec 148 (11), 346-347 PubMed.
Other sources of information
- BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn.