Aglepristone
Synonym(s): RU 534
Introduction
Name
- Aglepristone.
Class of drug
- Progesterone receptor antagonist.
Description
Chemical name
- (8S,11R,13S,14S,17R)-11-(4-dimethylaminophenyl)-17-hydroxy-13-methyl-17-[(Z)-prop-1-enyl]-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
Molecular formula
- C29H37NO2
Molecular weight
- 431.60958
Physical properties
- Clear yellow oily solution.
Storage requirements
- Shelf life of 3 years.
- Once opened must be used within 28 days and discarded if discoloration occurs.
- As the available veterinary formulation contains no antibacterial preservative, swab the opening's membrane with suitable disinfectant each time before withdrawing the dose to be administered.
- Protect the bottle from light.
Uses
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Administration
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Pharmacokinetics
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Precautions
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Withdrawal Periods
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Adverse Reactions
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
- Agaoglu A R, Sch��fer-Somi S, Kaya D et al (2011) The intravaginal application of misoprostol improves induction of abortion with aglepristone. Theriogenology 76 (1), 74-82 PubMed.
- Rigau T, Rodr��guez-Gil J E, Garc��a F et al (2011) Partial foetal retention following aglepristone treatment in a bitch. Reprod Domest Anim 46 (4), 738-741 PubMed.
- Pettersson C H, Tidholm A (2009) Safety and efficacy of mid-term pregnancy termination using aglepristone in dogs. JSAP 50 (3), 120-123 PubMed.
- Sch��fer-Somi S, Aksoy O A, Beceriklisoy H B et al (2007) Repeated induction of abortion in bitches and the effect on plasma concentrations of relaxin, progesterone and estradiol-17beta. Theriogenology 68 (6), 889-895 PubMed.
- Corrada Y, Garc��a P, de la Sota P E et al (2005) Decrease of body temperature after aglepristone treatment in bitches. Anim Reprod Sci 87 (3-4), 295-299 PubMed.
- Fieni F, Martal J, Marnet P G et al (2001) Hormonal variation in bitches after early or mid-pregnancy termination with aglepristone (RU534). J Reprod Fertil Suppl 57, 243-248 PubMed.
- Galac S, Kooistra H S, Butinar J et al (2000) Termination of mid-gestation pregnancy in bitches with aglepristone, a progesterone receptor antagonist. Theriogenology 53 (4), 941-950 PubMed.
- Hubler M, Arnold S (2000) [Prevention of pregnancy in bitches with the progesterone antagonist aglepristone (alizone)]. Schweiz Arch Tierheilkd 142 (7), 381-386 PubMed.
Other sources of information
- BSAVA Small Animal Formulary. Ramsey I (2017) 9th edn.