ISSN 2398-2993      

Oxfendazole

obovis
Contributor(s):

Vetstream Ltd

Andrea Tarr

Synonym(s): Benzimidazole, White drench


Introduction

Name

  • Oxfendazole.

Class of drug

  • Endoparasiticide.
  • Benzimidazole.

Description

Chemical name

  • [5-(phenylsulfinyl)-1H-benzimidazol-2-yl]carbamic acid methyl ester.

Molecular formula

  • C15H13N3O3S.

Molecular weight

  • 315.35 g/mol−1.

Physical properties

  • Powder.
  • White suspension.
  • Intra-ruminal device.

Storage requirements

  • Store in a dry environment.
  • Protect from frost.
  • Protect from direct sunlight.
  • Do not store or transport above 25°C/77°F.

Uses

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Indications

Administration

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Pharmacokinetics

Precautions

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Interactions

With other drugs

  • Intraruminal devices are not always compatible with other intraruminal devices; always check the specific product information.
  • Ensure appropriate time is left between lungworm vaccination and dosing with oxfendazole. Check specific product information.
  • Bromsalan flukicides (eg, dibromsalan, tribromsalan): oxfendazole should not be given concurrently with these agents; abortions in cattle have been reported.

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

Other sources of information

  • The Veterinary Formulary (1998) 4th edn. Ed: Bishop Y. British Veterinary Association and Royal Pharmaceutical Society, UK.
  • European Medicines Agency. Veterinary Medicines and Inspections. EMEA/MRL/888/03-FINAL ( 2004) Committee for Veterinary Medicinal Products. Oxfendazole Summary Report (4) https://www.ema.europa.eu (pdf online).
  • NOAH Compendium (2016) Bovex 2.265% Oral Suspension. Website: https://www.noahcompendium.co.uk
  • NOAH Compendium (2016) Autoworm Finisher 6250 mg Pulsatile-Release Intraruminal Device. Website: https://www.noahcompendium.co.uk
  • NOAH Compendium. Autoworm First Grazer 8750 mg Pulsatile-Release Intraruminal Device. Website: https://www.noahcompendium.co.uk.
  • VMD Product Information Database. Teat Dip or Spray Solution. Website: https://www.vmd.defra.gov.uk
  • VMD Product Information Database. Autoworm Finisher 6250 mg Pulsatile-Release Intraruminal Device. https://www.vmd.defra.gov.uk (pdf online).
  • VMD Product Information Database. Autoworm First Grazer 8750 mg Pulsatile-Release Intraruminal Device​. Website: https://www.vmd.defra.gov.uk (pdf online).
  • VMD Product Information Database. Autoworm First Grazer 8750 mg Pulsatile-Release Intraruminal Device. Wesbite: https://www.vmd.defra.gov.uk.
  • VMD Product Information Database. Autoworm Finisher 6250 mg Pulsatile-Release Intraruminal Device. https://www.vmd.defra.gov.uk.
  • VMD Product Information Database. Bovex 2.265% w/v Oral Suspension for Cattle and Sheep. Website: https://www.vmd.defra.gov.uk.
  • Boehringer Ingelheim. Symanthic Oral Suspension. Website: https://www.bi-vetmedica.com.
  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
  • Veterinary Medicines Directorate (VMD) Product Information Database. Website: www.vmd.defra.gov.uk.

Organisation(s)

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