Introduction

Name

• Hyoscine butylbromide combined with metamizole.

Class of drug

• Quaternary ammonium spasmolytic combined with analgesic and anti-inflammatory.

Description

Molecular formula

• Hyoscine butylbromide: C₂₁H₃₀BrNO₄⁺.
• Metamizole: C₁₃H₁₇N₃O₄S.

Molecular weight

• Hyoscine butylbromide: 360.474 g/mol.
• Metamizole: 331.3603 g/mol-1.

Physical properties

• Clear, yellow solution.

Storage requirements

• Do not store above 25°C/77°F.
• Protect from light.

Uses

Indications

• Pain with enteritis and digestive disturbance, diarrhea, esophageal obstruction Esophagus: diseases and disorders Esophageal obstruction: probang technique, post parturient relief of pain, functional tympanitis Ruminal bloat. Specific products may not be licensed for all of the indications shown. Please check the specific product information to ensure you adhere to licensing rules or refer to the Cascade The cascade: prescribing unauthorised medicines in the UK as necessary.

Administration

Pharmacokinetics

Precautions

Interactions

With other drugs

• Concurrent use of drugs that induce hepatic microsomal enzymes, eg barbiturates or phenylbutazone Phenylbutazone, reduces the duration of action of metamizole.
• Risk of gastro-intestinal bleeding is increased upon concurrent use of glucocorticoids with metamizole.

Withdrawal Period

Adverse Reactions

Further Reading

Publications

Refereed Papers

• Recent references from PubMed and VetMedResource.

Other sources of information

• National Library of Medicine (2023) Metamizole. Website: www.pubchem.ncbi.nlm.nih.gov.
• National Office of Animal Health (2022) Spasmium Comp. 500 mg/ml + 4 mg/ml Solution for injection. In: NOAH Compendium of Datasheets. Website: www.noahcompendium.co.uk.
• VMD (2022) DEFRA Summary of product characteristics. Buscopan Compositum. Website: www.vmd.defra.gov.uk (pdf download).
• VMD (2015) Product Details - Spasmium Comp. 500 mg/ml + 4 mg/ml Solution for Injection. www.vmd.defra.gov.uk.
• Boehringer Ingelheim (2012) Buscopan Compositum Product information. Website: www.boehringer-ingelheim.com.au (pdf download).

Organisation(s)

• National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.