ISSN 2398-2993      

Cefoperazone

obovis
Contributor(s):

Vetstream Ltd

Andrea Tarr

Synonym(s): Third generation semi-synthetic cephalosporin


Introduction

Name

  • Cefoperazone.

Class of drug

  • Third generation semi-synthetic cephalosporin.
  • EMA Class B (Restrict use).
  • The World Health Organization (WHO) Critically Important Antimicrobials for Human Medicine; Critically Important – Highest Priority.

Description

Chemical name

  • (6R,7R)-7-[[(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid.

Molecular formula

  • C25H27N9O8S2.

Molecular weight

  • 645.67 g/mol−1.

Physical properties

  • Intramammary suspension: white to off-white oily suspension.

Storage requirements

  • Store <25°C/77°F.

Uses

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Indications

Administration

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Pharmacokinetics

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Precautions

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Interactions

With other drugs

  • There is a rare possibility of cross reaction with other beta-lactam antibiotics.
  • Cefoperazone is not compatible with aminoglycoside antibiotics such as streptomycin Streptomycin, neomycin Neomycin and gentamycin Gentamicin.
  • The simultaneous administration of potentially nephrotoxic drugs may extend the elimination of cefoperazone.

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Wilson C D, Agger N, Gilbert G A et al (1986) Field trials with cefoperazone in the treatment of bovine clinical mastitis. Vet Rec 118 (1), 17-19 PubMed.

Other sources of information

  • World Organization for Animal Health (OIE) List of Antimicrobial Agents of Veterinary Importance. World Organization for Animal Health (2021) List of Antimicrobial Agents of Veterinary Importance. Website: www.woah.org.
  • Veterinary Medicines Directorate (2020) Pathocef 250 mg Intramammary Suspension – Summary of Product Characteristics. Website: www.vmd.defra.gov.uk (pdf download).
  • The European Agency for the Evaluation of Medicinal Products (1998) Committee for Veterinary Medicinal Products – Cefoperazone. Website: www.ema.europa.eu (pdf download).
  • Wikipedia (online) Cefoperazone. Website: https://en.wikipedia.org.

Organisation(s)

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