ISSN 2398-2993      

Cefalexin

obovis
Contributor(s):

Vetstream Ltd

Andrea Tarr


Introduction

Name

  • Cefalexin.
  • Cefalexin sodium (for IM treatment of cefalexin-sensitive infections in cattle).
  • Cefalexin-monohydrate (for the intramammary treatment of mastitis in lactating cows and for the intramuscular treatment of infections in veal calves).
  • Cefalexin-benzathine (for the intramammary treatment and prevention of infections in dry cows).

Class of drug

  • 1st generation cephalosporin antibiotic (European Medicines Agency Category C).
  • Member of beta-lactam group.

Description

Chemical name

  • (6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid.

Molecular formula

  • C16H17N3O4S.

Molecular weight

  • 347.4.

Physical properties

  • White to off-white crystalline powder.

Storage requirements

  • Suspension for injection:
    • Do not store above 30°C/86°F.
    • Protect from light.
    • Following withdrawal of the first dose, use the product within 28 days.
  • In the presence of water hydrolysis of cefalexin occurs. It is important, therefore, that a dry syringe is used when extracting suspension for injection to avoid contaminating the remaining contents of the vial with drops of water.

Uses

This article is available in full to registered subscribers

Sign up now to start a free trial to access all Vetlexicon articles, images, sounds and videos, or Login

Indications

Administration

This article is available in full to registered subscribers

Sign up now to start a free trial to access all Vetlexicon articles, images, sounds and videos, or Login

Pharmacokinetics

Precautions

This article is available in full to registered subscribers

Sign up now to start a free trial to access all Vetlexicon articles, images, sounds and videos, or Login

Interactions

With other drugs

  • Bacteriostatic antibiotics: the bactericidal activity of cephalosporins may be affected by the concomitant use of bacteriostatic agents, eg erythromycin Erythromycin, tetracycline Oxytetracycline.
  • Amphotericin and loop diuretics: there may be an increased risk of nephrotoxicity if used with cephalosporins.

Withdrawal Period

This article is available in full to registered subscribers

Sign up now to start a free trial to access all Vetlexicon articles, images, sounds and videos, or Login

Adverse Reactions

This article is available in full to registered subscribers

Sign up now to start a free trial to access all Vetlexicon articles, images, sounds and videos, or Login

Further Reading

Publications

Refereed papers

Other sources of information

  • MSD Animal Health Hub (2020) CeporexTM 180 mg/ml Suspension for Injection for Cattle, Cats and Dogs. Website: www.msd-animal-health-hub.co.uk.
  • Veterinary Medicines Directorate (2008) Ubrolexin Intramammary Suspension. Boehringer Ingelheim Animal Health, UK. Website: www.vmd.defra.gov.uk.
  • The European Agency for the Evaluation of Medicinal Products (1999) Committee for Veterinary Medicinal Products - Cefalexin Summary Report. Website: www.ema.europa.eu (pdf download).

Organisation(s)

MEMBER BENEFIT

Can’t find what you’re looking for?

We have an ever growing content library on Vetlexicon so if you ever find we haven't covered something that you need please fill in the form below and let us know!

 
 
 
 

To show you are not a Bot please can you enter the number showing adjacent to this field