canis - Articles
Aglepristone
Synonym(s): RU 534
Introduction
Name
- Aglepristone.
Class of drug
- Progesterone receptor antagonist.
- Aglepristone (Alizine) is available in Europe, but not the United States, for medical abortion in the bitch. USA importation with permit from FDA is possible.
Description
Chemical name
- (8S,11R,13S,14S,17R)-11-(4-dimethylaminophenyl)-17-hydroxy-13-methyl-17-[(Z)-prop-1-enyl]-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one.
Molecular formula
- C29H37NO2.
Molecular weight
- 431.60958.
Physical properties
- Clear yellow oily solution.
Storage requirements
- Shelf life of 3 years.
- Once opened must be used within 28 days and discarded if discoloration occurs.
- As the available veterinary formulation contains no antibacterial preservative, swab the bottle membrane with suitable disinfectant each time, before withdrawing the dose to be administered.
- Protect the bottle from light.
Uses
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Administration
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Precautions
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Adverse Reactions
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
- Gogny A & Fiéni F (2016) Aglepristone: A review on its clinical use in animals. Theriogenology 85 (4), 555–566 PubMed.
- Ros L, Ström Holst B & Hagman R (2014) A retrospective study of bitches with pyometra, medically treated with aglepristone Theriogenology 82 (9),1281–1286 PubMed.
- Bigliardi E, Bresciani C, Callegari D et al (2014) Use of aglepristone for the treatment of P4 induced insulin resistance in dogs. J Vet Sci 15 (2), 267-271 PubMed.
- Agaoglu A R, Schäfer-Somi S, Kaya D et al (2011) The intravaginal application of misoprostol improves induction of abortion with aglepristone. Theriogenology 76 (1), 74-82 PubMed.
- Rigau T, Rodríguez-Gil J E, García F et al (2011) Partial foetal retention following aglepristone treatment in a bitch. Repro Domest Anim 46 (4), 738-741 PubMed.
- Georgiev P, Bostedt H, Goericke-Pesch S et al (2010) Induction of abortion with aglepristone in cats on day 45 and 46 after mating. Reprod Domest Anim 45 (5), e161–167 PubMed.
- Fontbonne A, Fontaine E, Lévy X et al (2009) Induction of parturition with aglepristone in various sized bitches of different breeds. Repro Domest Anim 44 (2),170-173 PubMed.
- Pettersson C H & Tidholm A (2009) Safety and efficacy of mid-term pregnancy termination using aglepristone in dogs. JSAP 50 (3), 120-123 PubMed.
- Schäfer-Somi S, Aksoy O A, Beceriklisoy H B et al (2007) Repeated induction of abortion in bitches and the effect on plasma concentrations of relaxin, progesterone and estradiol-17beta. Theriogenology 68 (6), 889-895 PubMed.
- Bhatti S F, Duchateau L, Okkens A C et al (2006) Treatment of growth hormone excess in dogs with the progesterone receptor antagonist aglepristone. Theriogenology 66 (4),797-803 PubMed.
- Corrada Y, García P, de la Sota P E et al (2005) Decrease of body temperature after aglepristone treatment in bitches. Anim Reprod Sci 87 (3-4), 295-299 PubMed.
- Meisl D, Hubler M & Arnold S (2003) Treatment of fibroepithelial hyperplasia (FEH) of the mammary gland in the cat with the progesterone antagonist Aglépristone (Alizine). Schweiz Arch Tierheilkd 145 (3),130–136 PubMed.
- Fieni F, Martal J, Marnet P G et al (2001) Hormonal variation in bitches after early or mid-pregnancy termination with aglepristone (RU534). J Repro Fertil Suppl 57, 243-248 PubMed.
- Galac S, Kooistra H S, Butinar J et al (2000) Termination of mid-gestation pregnancy in bitches with aglepristone, a progesterone receptor antagonist. Theriogenology 53 (4), 941-950 PubMed.
- Hubler M, Arnold S (2000) [Prevention of pregnancy in bitches with the progesterone antagonist aglepristone (alizone)]. Schweiz Arch Tierheilkd 142 (7), 381-386 PubMed.
Other sources of information
- Ramsey I (2017) BSAVA Small Animal Formulary. Part A: Canine and Feline. 9th edn. BSAVA, UK.
- Romagnoli S, Fieni F, Prats A et al (2006) Treatment of Canine Open-Cervix and Closed-Cervix Pyometra with Combined Administration of Aglepristone and Misoprostol. In: Proceedings Congress European Vet Soc Small Anim Repro, pp 287.