canis - Articles
Trilostane
Synonym(s): WIN 24, 540, Modrenal, Vetoryl
Introduction
Name
- Trilostane.
Class of drug
- Adrenocortical suppressant (inhibits the 3-beta-hydroxysteroid dehydrogenase isomerase enzyme system).
Description
Chemical name
- (4-alpha, 5-alpha, 17-beta)-4,5-epoxy-3,17-dihydroxyandrost-2-ene-2-carbonitrile.
Molecular formula
- C20H27NO3.
Molecular weight
- 329.44.
Physical properties
- White or almost white crystalline powder.
Storage requirements
- Store in a dry place.
Uses
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Administration
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Pharmacokinetics
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Precautions
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Withdrawal Periods
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Adverse Reactions
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Further Reading
Publications
Refereed papers
- Recent references from VetMedResource and PubMed.
- Ramsey I & Ristic J (2007) The diagnosis of canine hyperadrenocorticism. In Practice 29, 226-454.
- Ramsey I & Neiger R (2007) The treatment of canine hyperadrenocorticism. In Practice 29, 512-519.
- Bell R, Neiger R, McGrotty Y & Ramsey I K (2006) Study of the effects of once daily trilostane administration on cortisol concentrations and ACTH responsiveness in hyperadrenocorticoid dogs. Vet Rec 159, 277-281 PubMed.
- Ramsey I (2006) Diagnosis of canine hyperadrenocorticism. UK Vet 11 (1), 21-28.
- Ramsey I (2005) Pathophysiology of hyperadrenocorticism. UK Vet 10 (8), 31-37.
- Barker E, Campbell S, Tebb A, Neiger R, Herrtage M E, & Ramsey I K (2005) A comparison of the survival times of dogs treated for hyperadrenocorticism with trilostane or mitotane. JVIM 19, 810-815 PubMed.
- Chapman P S, Kelly D F, Archer J, Brockman D J, Neiger R (2004) Adrenal necrosis in a dog receiving trilostane for the treatment of hyperadrenocorticism. JSAP 45, 307-310 PubMed.
- Wenger M, Sieber-Ruckstuhl NS, Muller C and Reusch CE (2004) Effect of trilostane on serum concentrations of aldosterone, cortisol, and potassium in dogs with pituitary-dependent hyperadrenocorticism. Am J Vet Res 65, 1245-1250 PubMed.
- Neiger R (2003) Treatment of canine hyperadrenocorticism (Cushing's Disease) with trilostane. UK Vet 8 (2), 19-22.
- Ruckstuhl N S, Nett C S & Reusch C E (2002) Results of clinical examinations, laboratory tests, and ultrasonography in dogs with pituitary-dependent hyperadrenocorticism treated with trilostane. Am J Vet Res 63, 506512.
- Neiger R, Ramsey I, O'Connor J, Hurley K J & Mooney C T (2002) Trilostane treatment of 78 dogs with pituitary-dependent hyperadrenocorticism. Vet Rec 150,799-804 PubMed.
- Neiger R & Hurley K (2000) Long-term efficacy and safety of trilostane for treatment of canine hyperadrenocorticism. JVIM 14, 376.
Other sources of information
- www.canine-cushings.co.uk
- Vetoryl® Capsules: www.dechra-us.com
- Eastwood J M, Elwood C M (2003) Prolonged hypoadrenocorticism in five dogs treated with trilostane for pituitary dependent hyperadrenocorticism(abstract). Proceedings of the British Small Animal Veterinary Association, BSAVA Publications, UK, 587.
- Eastwood J M, Elwood C M & Hurley K J (2001) Trilostane treatment of four dogs with functional adrenocortical neoplasia. ESVIM Congress, Dublin.
- Neiger R & Hurley K (2001) 24 hour cortisol values in dogs with hyperadrenocorticism on trilostane. BSAVA Congress, Birmingham.
- Ramsey I & McGrotty Y (2001) The effect of trilostane on ACTH stimulation tests performed at two different times post-treatment. ESVIM Congress, Dublin.
- Hurley K (1998) Trilostane in the treatment of canine hyperadrenocorticism. ESVIM Congress, Vienna, Austria.