Pimobendan in Dogs (Canis) | Vetlexicon
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Pimobendan

ISSN 2398-2942


Introduction

Name

  • USAN.
  • rINN.

Class of drug

  • Positive inotrope.
  • Vasodilator.

Description

Chemical name

  • 4,5-Dihydro-6-[2-(p-methyoxyphenyl)-5-benzimidazolyl]-5-methyl-3(2H-pyridazinone).

Molecular formula

  • C19H18N4O2.

Molecular weight

  • 334.4.

Storage requirements

  • Do not store above 25°C.
  • Store in a dry place.
  • Vials are single use.  
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Uses

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Administration

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Pharmacokinetics

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Precautions

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Withdrawal Periods

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from VetMedResource and PubMed.
  • Boswood A, Haggstrom J, Gordon S et al (2016) Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study-A Randomized Clinical Trial.��� JVIM 30, 1765-1779 PubMed.
  • Summerfield N, Boswood A, O’Grady M, Gordon S, Dukes-McEwan J, Oyama M, Smith S, Patteson M, French A, Culshaw G, Braz-Ruivo L, Estrada A, O’Sullivan M, Loureiro J, Willis R and Watson P (2012) Efficacy of Pimobendan in the Prevention of Congestive Heart Failure or Sudden Death in Doberman Pinschers with Preclinical Dilated Cardiomyopathy (The PROTECT Study). J Vet Intern Med 26, 1337-1349 PubMed.
  • Bernay F, Bland J M et al (2010) Efficacy of spironolactone on survival in dogs with naturally occurring mitral regurgitation caused by myxomatous mitral valve disease. JVIM 24, 331-341 PubMed.
  • Atkins C, Bonagura S et al (2009) Guidelines for the diagnosis and treatment of canine chronic valvular heart disease. ACVIM consensus statement. JVIM 23, 1142-1150 PubMed.
  • Haggstrom J, Boswood A et al (2008) Effect of pimobendan or benazepril hydrochloride on survival times in dogs with congestive heart failure caused by naturally occurring myxomatous valvular disease: The QUEST study. JVIM 22, 1124-1135 PubMed.
  • O'Grady M R, Minors S L et al (2009) Effect of pimobendan on case fatality rate in Doberman Pinschers with congestive heart failure caused by dilated cardiomyopathy. JVIM 22, 897-904 PubMed.
  • Smith P J, French A et al (2005) Efficacy and safety of pimobendan in canine heart failure caused by myxomatous mitral valve disease. JSAP 46, 121-130.

Other sources of information

  • The Veterinary Formulary. 5th edn (2001) Ed: Bishop Y. British Veterinary Association and Pharmaceutical Press.
  • Lombard C W et al (2000) Clinical experience with pimobendan. VCS Proceedings. Spring Meeting, UK.
  • Luis Fuentes V, Kleeman R et al (1998) The effect of a novel inodilator pimobendan on heart failure status in Cocker Spaniels and Dobermanns with idiopathic dilated cardiomyopathy. Proccedings of the BSAVA Congress. p 284.
  • Vetmedin Technical Dossier published by Boehringer Ingelheim Vetmedica.