canis - Articles
Sarolaner
Synonym(s): Simparica
Introduction
Name
- Sarolaner (Simparica).
Class of drug
- Systemic acaricide and insecticide belonging to the isoxazoline group.
Description
Chemical name
- 1-(5’-((5S)-5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3’-H-spiro(azetidine-3,1’-(2)benzofuran)-1-yl)-2-(methylsulfonyl)ethanone.
Molecular formula
- C23H18Cl2F4N2O5S
Molecular weight
- 625.9
Physical properties
- Chewable tablets (liver flavored).
Storage requirements
- Store at or below 30°C (86°F) with excursions permitted up to 40°C (104°F).
- Keep out of the sight and reach of children.
Print off the owner factsheet Medication: Sarolaner to give to your client.
Uses
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Administration
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Pharmacokinetics
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Precautions
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Withdrawal Periods
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Adverse Reactions
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Further Reading
Publications
Refereed Papers
- Recent references from VetMedResource and PubMed.
- Rugg D, Little S & Breitschwerdt E (2016) Special issue: Sarolaner - a novel ectoparasiticide for dogs. Vet Parasitol 222, 1-72.
- Geurden T, Becskei C, Grace S, Strube C, Doherty P, Liebenberg J, Mahabir SP, Slootmans N, Lloyd A, Six RH (2016) Efficacy of a novel oral formulation of sarolaner (Simparica™) against four common tick species infesting dogs in Europe. Vet Parasitol 222, 33-36 PubMed.
- Becskei C, De Bock F, Illambas J, Mahabir SP, Farkas R, Six RH (2016) Efficacy and safety of a novel oral isoxazoline, sarolaner (Simparica™) in the treatment of naturally occurring flea and tick infestations in dogs presented as veterinary patients in Europe. Vet Parasitol 222, 49-55 PubMed.
- Cherni JA, Malabir SP, Six RH (2016) Efficacy and safety of sarolaner (Simparica™) against fleas on dogs presented as veterinary patients in the United States. Vet Parasitol 222, 43-48 PubMed.
- Six RH, Becskei C, Carter L, Gale B, Young DR, Mahabir SP, Chapin S, Myers MR (2016) Evaluation of the speed of kill, effects on reproduction, and effectiveness in a simulated infested-home environment of sarolaner (Simparica™) against fleas on dogs. Vet Parasitol 222, 23-27 PubMed.
- Six RH, Geurden T, Carter L, Everett WR, McLoughlin A, Mahabir SP, Myers MR, Slootmans N (2016) Evaluation of the speed of kill of sarolaner (Simparica™) against induced infestations of three species of ticks (Amblyomma maculatum, Ixodes scapularis, Ixodes ricinus) on dogs. Vet Parasitol 222, 37-42 PubMed.
- Six RH, Becskei C, Mazaleski MM, Fourie JJ, Mahabir SP, Myers MR, Slootmans N (2016) Efficacy of sarolaner, a novel oral isoxazoline, against two common mite infestations in dogs: Demodex spp. and Otodectes cynotis. Vet Parasitol 222, 62-66 PubMed.
- Becskei C, De Bock F, Illambas J, Cherni JA, Fourie JJ, Lane M, Mahabir SP, Six RH (2016) Efficacy and safety of a novel oral isoxazoline, sarolaner (Simparica™), for the treatment of sarcoptic mange in dogs. Vet Parasitol 222, 56-61 PubMed.
Other sources of information
- Simparica.com
- Zoetis product datasheet: Simparica. Website: www.zoetis.co.uk/simparica-datasheet.aspx
- European Medicines Agency: Simparica. Website: www.ema.europa.eu/en/documents/product-information/simparica-epar-product-information_en.pdf
- Zoetis Product Leaflet (November 2020): Simparica. Website: https://www.zoetisus.com/products/dogs/simparica/pdf/simparica-pi.pdf
- Zoetis: Simparica (sarolaner) chewables: www.zoetispetcare.com/products/simparica/