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Blood biochemistry: total globulin
Synonym(s): TGG
Overview
- Contains alpha-, beta- and gamma-globulin fractions.
- Alpha- and beta- further subdivided into alpha-1 and -2 and beta-1 and -2.
- Total gobulin is a calculated result ([total protein] Blood biochemistry: total protein minus [albumin] Blood biochemistry: albumin = total globulin).
- Examination of individual fractions following electrophoretic separation more specific Serum protein electrophoresis.
Uses
In combination
- Immunodeficiency.
- Monoclonal gammopathies.
- Acute, subacute and chronic inflammation.
- Auto-immune disease.
Sampling
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Tests
Methodologies
- Determined indirectly (calculated) by difference in total protein Blood biochemistry: total protein and albumin Blood biochemistry: albumin.
- Electrophoretic separation Serum protein electrophoresis of proteins is necessary to determine individual fractions.
Availability
- Readily available.
- Contact individual commercial laboratories for availability of electrophoresis.
Technique intrinsic limitations
- Must be interpreted in conjunction with other laboratory and clinical findings.
Technician extrinsic limitations
- Electrophoresis is a specialized technique.
Result Data
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Further Reading
Publications
Refereed papers
- Recent references from VetMedResource and PubMed.
- Day M J (1996) Serial monitoring of clinical, hematological and immunological parameters in canine autoimmune hemolytic anemia. JSAP 37 (11), 523-534.
Other sources of information
- Ettinger S J & Feldman E C (2000) Eds. Textbook of Veterinary Internal Medicine. 5th edn. W B Saunders & Co, USA.
- Kaneko J J, Harvey J W & Brass M L (1997) Eds. Clinical Biochemistry of Domestic Animals. 5th edn. Academic Press, USA.
- Duncan J R, Prasse K W & Mahaffey E A (1994) Veterinary Laboratory Medicine. Clinical Pathology. 3rd edn. Iowa University Press, USA.