canis - Articles
Blood biochemistry: total calcium
Synonym(s): Ca
Overview
- Major constituent of bones and teeth.
- Physiological functions include nerve transmission and blood clotting.
- Regulated by parathyroid hormone, calcitonin and vitamin D.
- Important marker of bone disease and parathyroid function.
- Comprises three fractions: ionized Blood biochemistry: ionized calcium (50%, biologically active), protein bound (40%) and chelated to anions (10%).
Uses
Alone
- With ionized calcium Blood biochemistry: ionized calcium and parathyroid hormone assay PTH assay for investigation of calcium homeostasis.
- Investigation of bone diseases.
- Investigation of seizures Epilepsy: idiopathic or weakness.
- Assessment of renal insuffiency Kidney: chronic kidney disease (CKD).
- Assessment of patients with lymphoproliferative diseases Lymphoproliferative disease.
Sampling
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Tests
Methodologies
- Colorimetric assay most commonly used.
- May be measured directly by atomic absorption.
Availability
- Routine availability at commercial laboratories.
Technique intrinsic limitations
- Test results only significant in conjunction with other laboratory results and clinical findings.
Result Data
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Further Reading
Publications
Refereed papers
- Recent references from VetMedResource and PubMed.
- Dhupa N, Proulx J (1998) Hypocalcemia and hypomagnesemia. Vet Clin North Am Small Anim Pract 28 (3), 587-608.
- Weir E C et al (1988) Humoral hypercalcemia of malignancy in canine lymphosarcoma. Endocrinology 122 (2), 602-608.
Other sources of information
- Ettinger S J & Feldman E C (2000) Eds. Textbook of Veterinary Internal Medicine. 5th edn. W B Saunders & Co, USA.
- Kaneko J J, Harvey J W & Brass M L (1997) Eds. Clinical Biochemistry of Domestic Animals. 5th edn. Academic Press, USA.
- Duncan J R, Prasse K W & Mahaffey E A (1994) Veterinary Laboratory Medicine. Clinical Pathology. 3rd edn. Iowa University Press, USA.