Salbutamol toxicity in Dogs (Canis) | Vetlexicon
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Salbutamol toxicity

ISSN 2398-2942

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Synonym(s): Salbutamol sulfate, Albutarol sulfate

Introduction

  • Beta-2 adrenergic agonist, used to treat asthma in man.
  • Signs: tachycardia and muscle tremor.
  • Diagnosis: history, clinical signs.
  • Treatment: induce vomiting, treat symptoms.
  • Prognosis: good.

Presenting signs

  • Owner or someone in the household is an asthmatic.
  • Excitement.
  • Inability to stand.

Age predisposition

  • Toxicity may be seen more commonly in puppies which are more likely to chew novel items and ingest a relatively larger dose.

Cost considerations

  • Low cost in treating dogs with salbutamol intoxication.

Special risks

  • Diabetes, as salbutamol Salbutamol sulfate increases both blood sugar and insulin in healthy dogs.
  • Hyperthyroidism.
  • Hypertension.
  • Myocardial insufficiency.

Pathogenesis

Etiology

  • Dog consuming an asthmatic human's inhaler.

Pathophysiology

  • Salbutamol is considered to be predominantly a beta-2 agonist (relaxation of bronchial, uterine and vascular smooth muscles). Most adverse effects are dose related and those which would be expressed with sympathomimetic agents including increased heart rate, tremors, CNS excitement (nervousness) and dizziness.
  • Salbutamol is used principally in dogs for its effects on bronchial smooth muscle to alleviate bronchospasm or cough.

Timecourse

  • Signs develop within 0.5-8 hours of ingestion.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Mitten R W et al (1999) Salbutamol (albuterol) toxicity in a dog. Aust Vet Pract 29 (1), 10-14 VetMedResource.
  • Thursby-Pelham C (1996) Peculiar drug poisonings in pets. In Practice 18 (10), 478-487 VetMedResource.

Organisation(s)