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PIVKA

ISSN 2398-2942

Contributor(s) :


Synonym(s): Thrombotest, Proteins Induced by Vitamin K Absence or Antagonism

Overview

  • Prolongation of coagulation time absence of or abnormal forms of vitamin-K dependent Factors II, VII and X.

Uses

Alone

  • Evaluation of coagulation system in cases of suspected Vitamin K deficiency or antagonism, in combination with other tests.

Sampling

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Tests

Methodologies

  • Kit test that is suitable for standard fibrometer or some automated instruments.

Availability

  • Available from some commercial laboratories and/or in-practice testing laboratories.
  • Check with commercial laboratories regarding availability.

Validity

Sensitivity

  • Test has been validated for use in dogs.
  • May be more sensitive than PT and/or APTT for detection of absence or antagonism of Vitamin K dependent factors II, VII, and X.

Specificity

  • Not specific for underlying cause of Vitamin K absence or antagonism.

Technique intrinsic limitations

  • See quality control factors listed above.

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references from VetMedResource and PubMed.
  • Rozanski E A, Drobatz K J U, Hughes D, Scott M & Giger U (1999) Thrombotest (PIVKA) Test Results in 25 Dogs with Acquired and Hereditary Coagulopathies. J Vet Emer Crit Care 9 (2), 73-68.

Other sources of information

  • Center S A, Warner K L & Corbet J R (1998) PIVKA Clotting Times in Dogs with Suspected Coagulopathies. In: Proceedings 16th Annual ACVIM Forum. San Diego, CA, USA. Abstract No. 65.
  • Rozanski E A, Drobatz K J, Hughes D, Scottie M & Giger U (1998) Thrombotest (PIVKA), Prothrombin Time and Activated Thromboplastin Time Results in 25 Dogs with Acquired and Hereditary Coagulopathies. In: Proceedings 16th Annual ACVIM Forum. San Diego, CA, USA. Abstract No. 183.