canis - Articles
Insulin detemir
Introduction
Name
- Insulin detemir.
Class of drug
- Insulin analogue.
Description
Molecular formula
- C267H402O76N64S6.
Molecular weight
- 5913.
Physical properties
- Clear, sterile, aqueous solution containing 100 unit/mL.
Storage requirements
- Should be stored in refrigerator before use, but may be kept for 28 days at room temperature away from direct light and heat (<30°C) when contained within an insulin dosing pen that is in use.
- Once vials are in use, the manufacturer recommends discarding unused insulin after 28 days. However, problems have not been reported with continued use beyond 28 days.
Uses
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Administration
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Pharmacokinetics
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Precautions
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Withdrawal Periods
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Adverse Reactions
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
- Sparkes A, Cannon M, Church D et al (2016) ISFM consensus guidelines on the practical management of diabetes mellitus in cats. J Feline Med Surg 17 (3), 235-250 PubMed.
- Fracassi F, Corradini S, Hafner M et al (2015) Detemir insulin for the treatment of diabetes mellitus in dogs. JAVMA 247 (1), 73-78 PubMed.
- Thompson A L, Lathan P, Fleeman L M (2015) Update on insulin treatment for dogs and cats: insulin dosing pens and more. Vet Med (Auckl)��� 6, 129-142 PubMed.
- Gilor C, Graves T K (2010) Synthetic insulin analogs and their use in dogs and cats. Vet Clin North Am Small Anim Pract 40 (2), 297-307 PubMed.
- Gilor C, Ridge T K, Attermeier K J et al (2010) Pharmacodynamics of insulin detemir and insulin glargine assessed by an isoglycemic clamp method in healthy cats. J Vet Intern Med 24 (4), 870-874 PubMed.
Other sources of information
- Fracassi F, Hafner M, Corradini S, Boretti F, Sieber-Ruckstuhl N, Reusch C (2012) Use of insulin detemir in dogs with diabetes mellitus. Paper presented at the European College of Veterinary Internal Medicine-Companion Animal Congress, Maastricht, The Netherlands.
- Ford S L, Rand J S, Ghormley T M, Lynch H M (2010) Evaluation of Detemir Insulin in Diabetic Dogs Managed with Home Blood Glucose Monitoring. Paper presented at: American College of Veterinary Internal Medicine Forum 2010; Anaheim, California.