canis - Articles
Blindness
Introduction
- Cause:
- Intra-ocular disease (congenital disease (eg retinal dysplasia, collie eye anomaly), corneal opacity, uveitis (numerous causes), cataract, glaucoma, retinal detachment, inherited retinal degeneration, (eg progressive retinal atrophy, retinal pigment epithelial dystrophy), sudden acquired retinal degeneration syndrome (SARDS), dietary deficiency (eg Vitamin E), toxicity (eg ivermectin), intra-ocular neoplasia, intraocular hemorrhage and trauma).
- Optic nerve disease (optic neuritis, optic nerve or perineural tumor, compression of optic nerve by retrobulbar space occupying lesion).
- Intracranial disease (congenital disease (eg hydrocephalus), immune-mediated disease (eg GME, neoplasia, toxicity (eg lead), dietary deficiency (eg thiamine), metabolic disease (eg neuronal ceroid lipofuscinosis, lysosomal storage disease, hepatic encephalopathy), infections (eg distemper), consequence of hypoxia, trauma).
- It is important to localize where the lesion is occurring to target appropriate diagnostic procedures.
- Signs: obvious blindness.
- Diagnosis: recognition of blindness, diagnosis of underlying disease.
- Treatment: treat underlying cause where possible.
- Prognosis: variable; occasionally total blindness can be reversible depending on cause. Print off the owner factsheet Living with a blind dog to give to your client.
Acute presentation
- Dog obviously blind, bumping into objects, with or without ocular pain.
- Note that a dog with slowly developing and long-standing blindness will negotiate obstacles so well in a familiar environment that the owner may not notice obvious visual deficits.
Cost considerations
- Investigation of underlying disease may be costly especially if advanced diagnotic techniques are required, eg ERG, CSF, CT and MRI.
Pathogenesis
Predisposing factors
General
- Certain breeds have inherited ocular disease:
- Retinal dysplasia Retinal dysplasia , eg Bedlington terrier Bedlington Terrier , Golden Retriever Retriever: Golden , Cavalier King Charles spaniel Cavalier King Charles Spaniel.
- Progressive retinal atrophy (PRA) Retina: central progressive retinal atrophy (CPRA) Retina: generalized progressive retinal atrophy , eg Cocker spaniel English Cocker Spaniel , Minature and Toy Poodle Poodle: miniature Poodle: Toy , Minature Long-haired Dachshund Dachshund.
- Retinal pigment epithelial dystrophy (RPED) Retina: central progressive retinal atrophy (CPRA) , eg Briard Briard , Cocker spaniel English Cocker Spaniel.
- Cataract Cataract , eg Miniature Schnauzer Schnauzer: miniature , Standard Poodle Poodle: Standard , Labrador Retriever Retriever: Labrador.
- Goniodysgenesis (predisposes to primary glaucoma Glaucoma ), eg Basset Hound Basset Hound , Flat Coated Retriever Retriever: Flat-coated.
- Collie Eye Anomaly Collie eye anomaly , eg Border Collie Border Collie , Rough Collie Collie - Rough , Smooth Collie Collie - Smooth , Lancashire Heeler Lancashire Heeler , Shetland Sheepdog Shetland Sheepdog.
- Certain breeds predisposed to brain tumor, eg Boxer Boxer , Boston terrier Boston Terrier , Golden Retriever Retriever: Golden.
- See pathogenesis of uveitis Uveitis , glaucoma Glaucoma , cataract Cataract , retinal detachment Retina: detachment , optic neuritis Optic neuritis.
Timecourse
- Slow progressive sight loss.
- Acute or peracute blindness.
Diagnosis
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Treatment
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Prevention
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Outcomes
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Further Reading
Publications
Refereed papers
- Recent references from PubMed and VetMedResource.
- Gelatt K N (1998) Visual disturbance - where do I look? JSAP 38 (8), 328-335 PubMed.
Other sources of information
- Petersen-Jones S & Crispin S (2002)BSAVA Manual of Small Animal Ophthalmology.2nd edn. British Small Animal Veterinary Association. ISBN 0 905214 54 4.