canis - Articles
ACTH Assay
Overview
- ACTH is a peptide hormone secreted by the pituitary gland.
- Regulates production of steroid hormones from adrenal cortex.
- Secreted in pulsatile manner.
- Little overlap between [ACTH] in dogs with PDH and ADH.
- Useful discriminatory test once diagnosis of hyperadrenocorticism made.
Uses
In combination
- In combination with ACTH stimulation test ACTH stimulation test or low-dose dexamethasone suppression test Low-dose dexamethasone suppression test for discrimination of two forms of hyperadrenocorticism Hyperadrenocorticism.
- Very high levels seen in hypoadrenocorticism Hypoadrenocorticism.
Sampling
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Tests
Technique intrinsic limitations
- Some overlap in [ACTH] between normal and hyperadrenocorticoid dogs.
Technician extrinsic limitations
- Lability of hormone necessitates care in handling sample.
Result Data
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Further Reading
Publications
Refereed papers
- Recent references from VetMedResource and PubMed.
- Gould S M, Baines E A, Mannion P A, Evans H & Herrtage M E (2001) Use of endogenous ACTH concentration and adrenal ultrasonography to distinguish the cause of canine hyperadrenocorticism. JSAP 42, 113-121 PubMed.