bovis - Articles
Moxidectin
Introduction
Name
- Moxidectin.
Class of drug
- Macrocyclic lactone.
- Semi-synthetic milbemycin.
- Endectocide.
Description
Chemical name
- (2aE,4E,8E)-(52S,6R,62S,11R,13R,15S,17aR,20R,20aR,20bS)-62-[(1E)-1,3-dimethylbut-1-enyl]-52,62,10,11,14,15,17a,20,20a,20b-decahydro-20,20b-dihydroxy-52,6,8,19-tetramethylspiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,22-[2H]pyran]-42,17(32H,6H)-dione 42-(E)-(O-methyloxime).
Molecular formula
- C37H53NO8.
Molecular weight
- 639.84.
Physical properties
- Water Solubility (at 25 °C, pH 7): 51 ppb.
- Octanol-water Partition Coefficient: 58.3. Therefore, it is highly lipophilic.
- Photolysis half-life: 6.8 hours.
- Finished product: pour on solution, injectable solution.
Storage requirements
- In a cool environment (<25°C).
- Protect from light.
Uses
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Administration
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Pharmacokinetics
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Precautions
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Withdrawal Periods
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Adverse Reactions
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Further Reading
Publications
Refereed Papers
- Recent references from PubMed and VetMedResource.
Other sources of information
- Bishop Y (2005) Ed. The Veterinary Formulary. 6th edn. Published in association with the British Veterinary Association.
- NOAH compendium of datasheets.
- VMD product database.
- Cydectin SPC.