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Florfenicol
Synonym(s): Fluorinated synthetic analogue of the antibiotic thiamphenicol
Introduction
In the UK, Florfenicol is classified as category C (Caution) by the European Medicines Agency (EMA).
Name
- Florfenicol amine.
Class of drug
- Fluorinated synthetic analogue of the antibiotic thiamphenicol.
Description
Chemical name
- (1R,2S)-2-amino-3-fluoro-1-(4-methylsulfonylphenyl)propan-1-ol.
Molecular formula
- C₁₂H₁₄Cl₂FNO₄S.
Molecular weight
- 358.21 g/mol
Physical properties
- Clear, colorless/ yellow/ straw coloured slightly viscous solution for injection.
Storage requirements
- Check storage requirements for individual products.
- Some products have no specific storage requirements.
- Some require storage below 25°C and protection from freezing.
- Keep container in outer carton.
- Use or discard within 28 days of withdrawal of first dose.
- Some products have a limit on the number of times the product can be broached; products should be prescribed/ dispensed accordingly.
Uses
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Administration
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Pharmacokinetics
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Precautions
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Withdrawal Periods
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Adverse Reactions
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Further Reading
Publications
Refereed Papers
- Recent references from PubMed and VetMedResource.
Other sources of information
- Pubchem, Open Chemistry Database (2017) Florfenicol Amine. National Center for Biotechnology Information. PubChem Compound Database; CID=156406, https://pubchem.ncbi.nlm.nih.gov (accessed Oct. 2, 2017).
- Dairy UK (2017) Conditions of Use for Antibiotics Kanamycin, Cefquinome and Florfenicol. Dairy UK: 6th floor, 201 High Holborn, London WCIV 7EP. www.dairyUK.org.
- Yolande Bishop (2005) Ed The Veterinary Formulary 6th edn. Published in association with the British Veterinary Association.
- NOAH compendium of datasheets.
- European Medicines Agency (online) Categorisation of Antibiotics for Use in Animals for Prudent and Responsible Use. Website: www.ema.europa.eu (pdf download).