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Closantel

ISSN 2398-2993

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Synonym(s): Closantel sodium dihydrate, Anthelmintic

Introduction

Name

  • Closantel.
  • Usually available as Closantel sodium dihydrate.

Class of drug

  • Anthelmintic.
  • Endectocide.
  • Flukicide.
  • Salicylanilides.

Description

Chemical name

  • N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide.

Molecular formula

  • C22H14Cl2I2N2O2.

Molecular weight

  • 663.074 Da.

Physical properties

  • Solution for injection, pour on and oral solution.

Storage requirements

  • <25°C.
  • Protect from light.

Uses

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Administration

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Pharmacokinetics

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Precautions

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Withdrawal Periods

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Swan G E (1999) The pharmacology of halogenated salicylanilides and their anthelmintic use in animals. J S Afr Vet Assoc 70 (2), 61-70 PubMed.

Other sources of information

  • NOAH & VMD (2020) Joint Statement from the National Office of Animal Health (NOAH) and the Veterinary Medicines Directorate (VMD) on the Use of Flukicides in Dairy Cattle. Website: www.noah.co.uk (pdf download).
  • Norbrook (online) Closamectin Injection. In: Closamectin solution for injection for cattle and sheep. Website: www.norbrook.com.
  • Norbrook (online) Closamectin Pour-On. Website: www.noorbrook.com.
  • PubChem (online) Closantel. In: National Library of Medicine, National Centre for Biotechnology Information. Website: https://pubchem.ncbi.nlm.nih.gov.
  • Parasitipedia (online) Closantel: Safety Summary for Veterinary Use. Website: https://parasitipedia.net.
  • Veterinary Medicines Directorate (online) Product Database. Website: www.vmd.defra.gov.uk.